NDLI: Comparison of drug concentrations between whole blood and oral fluid.

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Comparison of drug concentrations between whole blood and oral fluid.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Langel, Kaarina Gjerde, Hallvard Favretto, Donata Lillsunde, Pirjo Øiestad, Elisabeth Leere Ferrara, Santo Davide Verstraete, Alain G.
Description	Country affiliation: Finland Author Affiliation: Langel K ( Department of Alcohol, Drugs, and Addiction, National Institute for Health and Welfare, Helsinki, Finland.)
Abstract	The relationship of drug concentrations between oral fluid and whole blood was evaluated by studying the linear correlation of concentrations and calculating the oral fluid to blood concentration ratios (OF/B) for different substances. Paired oral fluid and whole blood samples were collected from volunteers and persons suspected of drug use in four European countries. Oral fluid samples were collected with the SalivaâSampler™ device. All samples were analyzed for drugs of abuse and psychoactive medicines with validated gas and liquid chromatography-mass spectrometric methods. The median OF/B ratios were, for amphetamines 19-22, for opioids 1.8-11, for cocaine and metabolites 1.7-17, for tetrahydrocannabinol (THC) 14, for benzodiazepines 0.035-0.33, and for other psychoactive medicines 0.24-3.7. Most of the these results were close to theoretical values based on the physicochemical properties of the drugs and to values presented earlier, but there was a lot of inter-individual variation in the OF/B ratios. For all substances, except for lorazepam (R(2) = 0.031) and THC (R(2) = 0.030), a correlation between the oral fluid and whole blood concentrations was observed. Due to large variation seen here, drug findings in oral fluid should not be used to estimate the corresponding concentrations in whole blood (or vice versa). However, detection of drugs in oral fluid is a sign of recent drug use and oral fluid can be used for qualitative detection of several drugs, e.g. in epidemiological prevalence studies. By optimizing the sampling and the analytical cut-offs, the potential of oral fluid as a confirmation matrix could be enhanced.
File Format	HTM / HTML
ISSN	19427603
Issue Number	5
Volume Number	6
e-ISSN	19427611
Journal	Drug Testing and Analysis
Language	English
Publisher	Wiley
Publisher Date	2014-05-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Psychotropic Drugs Analysis Blood Saliva Chemistry Street Drugs Substance Abuse Detection Methods Blood Chemical Analysis Chromatography, Liquid Gas Chromatography-mass Spectrometry Humans Mass Spectrometry Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Environmental Chemistry Analytical Chemistry Pharmaceutical Science

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