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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gallwitz, Baptist |
| Description | Country affiliation: Germany Author Affiliation: Gallwitz B ( Department of Medicine IV, Eberhard Karls University, 72076 Tübingen, Germany. baptist.gallwitz@med.uni-tuebingen.de) |
| Abstract | Exenatide is the first incretin mimetic, introduced into type 2 diabetes mellitus therapy in 2005, with first approval in the US. It is a glucagon-like peptide-1 (GLP-1) receptor agonist that can be used for treatment by twice-daily injection. A long-acting release formulation for once-weekly injection is in clinical development. Clinical studies and postmarketing experience with exenatide have shown a significant and sustained reduction in glycosylated haemoglobin (HbA(1c)) by approximately 1% together with other gylcaemic parameters without an intrinsic risk for hypoglycaemias, and a reduction in bodyweight by 5.3 kg in 82 weeks. Blood pressure and lipids are also favourably affected, but hard cardiovascular endpoints are not yet available. Animal studies show an improvement of beta-cell function and an increase in beta-cell mass after exenatide treatment. The most frequent adverse events associated with exenatide therapy are nausea and antibody formation (both approximately 40%). Nausea, mostly mild and transient, was responsible for a 6% dropout rate in clinical studies. A recent review on the association of acute pancreatitis with exenatide treatment showed no increased risk (relative risk 1.0; 95% CI 0.6, 1.7). This review gives a benefit-risk assessment of exenatide. |
| File Format | HTM / HTML |
| ISSN | 01145916 |
| Issue Number | 2 |
| Volume Number | 33 |
| e-ISSN | 11791942 |
| Journal | Drug Safety |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2010-02-01 |
| Publisher Place | New Zealand (Aotearoa) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Diabetes Mellitus, Type 2 Drug Therapy Hypoglycemic Agents Pharmacology Therapeutic Use Peptides Venoms Animals Glucagon-like Peptide 1 Agonists Hemoglobin A, Glycosylated Drug Effects Humans Injections, Subcutaneous Risk Assessment Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Toxicology Pharmacology Pharmacology (medical) |
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