NDLI: Statin use and cataract surgery: a nationwide retrospective cohort study in elderly ethnic Chinese patients.

Please wait, while we are loading the content...

Risk factors for adverse symptoms during dipeptidyl peptidase-IV inhibitor therapy: a questionnaire-based study carried out by the Japan Pharmaceutical Association Drug Event Monitoring project in Kumamoto Prefecture.

Statin use and cataract surgery: a nationwide retrospective cohort study in elderly ethnic Chinese patients.

Development of a novel regulatory pharmacovigilance prioritisation system: an evaluation of its performance at the UK Medicines and Healthcare products Regulatory Agency.

Comparison of three methods (an updated logistic probabilistic method, the Naranjo and Liverpool algorithms) for the evaluation of routine pharmacovigilance case reports using consensual expert judgement as reference.

Allopurinol hypersensitivity: a systematic review of all published cases, 1950-2012.

Clinical hypotension with co-prescription of macrolide antibiotics and calcium-channel blockers in haemodialysis patients: a retrospective chart review.

Year: 2013 Volume: 36 Issue: 9

Year: 2013 Volume: 36 Issue: 8

Year: 2013 Volume: 36 Issue: 7

Year: 2013 Volume: 36 Issue: 6

Year: 2013 Volume: 36 Issue: 5

Year: 2013 Volume: 36 Issue: 4

Year: 2013 Volume: 36 Issue: 3

Year: 2013 Volume: 36 Issue: 2

Year: 2013 Volume: 36 Issue: 1

Year: 2013 Volume: 36 Issue: Supplementary 1

Year: 2012 Volume: 35

Year: 2011 Volume: 34

Year: 2010 Volume: 33

Year: 2009 Volume: 32

Year: 2008 Volume: 31

Statin use and cataract surgery: a nationwide retrospective cohort study in elderly ethnic Chinese patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lai, Chao-Lun Shau, Wen-Yi Chang, Chia-Hsuin Chen, Ming-Fong Lai, Mei-Shu
Spatial Coverage	China Taiwan
Description	Country affiliation: Taiwan Author Affiliation: Lai CL ( Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.)
Abstract	BACKGROUND: Since a report of lenticular opacities in dogs treated with high dosages of statins, the debate on the relationship between statin therapy and cataracts has not reached a conclusion. OBJECTIVE: The aim of this study was to evaluate the association between statin therapy and the risk of cataract surgery in an elderly ethnic Chinese population using time-dependent analysis to minimize immortal time bias. METHODS: A retrospective cohort study using the Longitudinal Health Insurance Database 2005 randomly sampled from the National Health Insurance Research Database, Taiwan, was conducted. A total of 50,165 adults aged between 65 and 90 years in 1998 without records of statin therapy or diagnosis of cataracts between July 1997 and December 1997 were included in the analysis. The first record of lens extraction within the follow-up period (1998-2009) was set as the study endpoint. A propensity score was derived using a logistic regression model to model the receipt of statin therapy as a function of the baseline characteristics for every subject. We used the time-dependent Cox regression model to test the relative hazard of undergoing cataract surgery between statin users and non-users, while use of statins was treated as a time-dependent variable, controlling for baseline age and individual propensity score. RESULTS: Of the 50,165 enrolled subjects, 17,670 individuals with an incident lens extraction were identified during a median follow-up of 10.7 years. The incidence of cataract surgery was 49.7/1,000 person-years in the statin-using period compared with 38.5/1,000 person-years in the statin-non-using period. The adjusted hazard ratio of cataract surgery was 1.20 (95 % CI 1.14-1.27; P < 0.001) in statin users compared with statin non-users. CONCLUSION: Statin therapy was associated with a modestly increased risk of cataract surgery. We suggest regular checks for lens opacity in statin users.
File Format	HTM / HTML
ISSN	01145916
Issue Number	10
Volume Number	36
e-ISSN	11791942
Journal	Drug Safety
Language	English
Publisher	Springer
Publisher Date	2013-10-01
Publisher Place	New Zealand (Aotearoa)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Cataract Extraction Statistics & Numerical Data Cataract Hydroxymethylglutaryl-coa Reductase Inhibitors Adverse Effects Aged Aged, 80 And Over Epidemiology Etiology China Ethnology Cohort Studies Databases, Factual Female Humans Administration & Dosage Incidence Male Propensity Score Proportional Hazards Models Retrospective Studies Risk Taiwan Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Toxicology Pharmacology Pharmacology (medical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Psychologic disorders and statin use: a propensity score-matched analysis.

Effects of statins in patients with coronary artery spasm: A nationwide population-based study.

Statins and new-onset diabetes: a retrospective longitudinal cohort study.

Amyloidosis and the risk of cancer: a nationwide population-based study.

Association of Statin Therapy and Risks of Cholelithiasis, Biliary Tract Diseases, and Gallbladder Procedures: Retrospective Cohort Analysis of a US Population.

Demographic determinants of response to statin medications.

Women with alopecia exhibit a higher risk for thyroid cancer: a nationwide cohort study.

The effect of fibrate-statin combination therapy on cardiovascular events: a retrospective cohort analysis.

Statin use and the risk of bladder cancer: a population-based case-control study.

Statin use and cataract surgery: a nationwide retrospective cohort study in elderly ethnic Chinese patients.

Similar Documents

Psychologic disorders and statin use: a propensity score-matched analysis.

Effects of statins in patients with coronary artery spasm: A nationwide population-based study.

Statins and new-onset diabetes: a retrospective longitudinal cohort study.

Amyloidosis and the risk of cancer: a nationwide population-based study.

Association of Statin Therapy and Risks of Cholelithiasis, Biliary Tract Diseases, and Gallbladder Procedures: Retrospective Cohort Analysis of a US Population.

Demographic determinants of response to statin medications.

Women with alopecia exhibit a higher risk for thyroid cancer: a nationwide cohort study.

The effect of fibrate-statin combination therapy on cardiovascular events: a retrospective cohort analysis.

Statin use and the risk of bladder cancer: a population-based case-control study.

Statin use and cataract surgery: a nationwide retrospective cohort study in elderly ethnic Chinese patients.