NDLI: Drug-Induced Hyperglycaemia and Diabetes.

Please wait, while we are loading the content...

Risk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Proton Pump Inhibitors, or Metoclopramide: A Population-Based Nested Case-Control Study.

Useful Interplay Between Spontaneous ADR Reports and Electronic Healthcare Records in Signal Detection.

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A National Analysis of Data from 10-Year Post-marketing Surveillance.

Drug-Induced Hyperglycaemia and Diabetes.

Association of Attorney Advertising and FDA Action with Prescription Claims: A Time Series Segmented Regression Analysis.

Impact on Drug Safety of Variation in Adherence: The Need for Routinely Reporting Measures of Dose Intensity in Medication Safety Studies Using Electronic Health Data.

Statistical Signal Detection as a Routine Pharmacovigilance Practice: Effects of Periodicity and Resignalling Criteria on Quality and Workload.

Year: 2015 Volume: 38 Issue: 11

Year: 2015 Volume: 38 Issue: 10

Year: 2015 Volume: 38 Issue: 9

Year: 2015 Volume: 38 Issue: 8

Year: 2015 Volume: 38 Issue: 7

Year: 2015 Volume: 38 Issue: 6

Year: 2015 Volume: 38 Issue: 5

Year: 2015 Volume: 38 Issue: 4

Year: 2015 Volume: 38 Issue: 3

Year: 2015 Volume: 38 Issue: 2

Year: 2015 Volume: 38 Issue: 1

Year: 2014 Volume: 37

Year: 2013 Volume: 36

Year: 2012 Volume: 35

Year: 2011 Volume: 34

Year: 2010 Volume: 33

Year: 2009 Volume: 32

Year: 2008 Volume: 31

Drug-Induced Hyperglycaemia and Diabetes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fathallah, Neila Slim, Raoudha Larif, Sofien Hmouda, Houssem Ben Salem, Chaker
Description	Country affiliation: Tunisia Author Affiliation: Fathallah N ( Department of Pharmacovigilance, Faculty of Medicine of Sousse, Sousse, Tunisia. neilafathallah@gmail.com.); Slim R ( Department of Clinical Pharmacology, Faculty of Medicine of Sousse, Avenue Mohamed Karoui, 4002, Sousse, Tunisia. neilafathallah@gmail.com.); Larif S ( Department of Pharmacovigilance, Faculty of Medicine of Sousse, Sousse, Tunisia.); Hmouda H ( Department of Pharmacovigilance, Faculty of Medicine of Sousse, Sousse, Tunisia.); Ben Salem C ( Department of Medical Intensive Care Unit, Sahloul University Hospital, Sousse, Tunisia.)
Abstract	Drug-induced hyperglycaemia and diabetes is a global issue. It may be a serious problem, as it increases the risk of microvascular and macrovascular complications, infections, metabolic coma and even death. Drugs may induce hyperglycaemia through a variety of mechanisms, including alterations in insulin secretion and sensitivity, direct cytotoxic effects on pancreatic cells and increases in glucose production. Antihypertensive drugs are not equally implicated in increasing serum glucose levels. Glycaemic adverse events occur more frequently with thiazide diuretics and with certain beta-blocking agents than with calcium-channel blockers and inhibitors of the renin-angiotensin system. Lipid-modifying agents may also induce hyperglycaemia, and the diabetogenic effect seems to differ between the different types and daily doses of statins. Nicotinic acid may also alter glycaemic control. Among the anti-infectives, severe life-threatening events have been reported with fluoroquinolones, especially when high doses are used. Protease inhibitors and, to a lesser extent, nucleoside reverse transcriptase inhibitors have been reported to induce alterations in glucose metabolism. Pentamidine-induced hyperglycaemia seems to be related to direct dysfunction in pancreatic cells. Phenytoin and valproic acid may also induce hyperglycaemia. The mechanisms of second-generation antipsychotic-associated hyperglycaemia, diabetes mellitus and ketoacidosis are complex and are mainly due to insulin resistance. Antidepressant agents with high daily doses seem to be more frequently associated with an increased risk of diabetes. Ketoacidosis may occur in patients receiving beta-adrenergic stimulants, and theophylline may also induce hyperglycaemia. Steroid diabetes is more frequently associated with high doses of glucocorticoids. Some chemotherapeutic agents carry a higher risk of hyperglycaemia, and calcineurin inhibitor-induced hyperglycaemia is mainly due to a decrease in insulin secretion. Hyperglycaemia has been associated with oral contraceptives containing high doses of oestrogen. Growth hormone therapy and somatostatin analogues may also induce hyperglycaemia. Clinicians should be aware of medications that may alter glycaemia. Efforts should be made to identify and closely monitor patients receiving drugs that are known to induce hyperglycaemia.
File Format	HTM / HTML
ISSN	01145916
Issue Number	12
Volume Number	38
e-ISSN	11791942
Journal	Drug Safety
Language	English
Publisher	Springer
Publisher Date	2015-12-01
Publisher Place	New Zealand (Aotearoa)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Diabetes Mellitus Chemically Induced Drug-related Side Effects And Adverse Reactions Hyperglycemia Pharmaceutical Preparations Classification Humans Insulin Metabolism Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Toxicology Pharmacology Pharmacology (medical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Drug-induced hypoglycaemia: an update.

Drug-induced thrombocytopenia: an updated systematic review, 2012.

Preventability of drug-related harms - part II: proposed criteria, based on frameworks that classify adverse drug reactions.

Drug-induced thrombocytopenia: an updated systematic review, 2008.

Drug-induced thrombosis: an update.

Primary hepatocytes as a model to analyze species-specific toxicity and drug metabolism.

Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review.

Comment on: 'Drug-Induced Hyperglycaemia and Diabetes'.

The human microbiome and therapeutics.

Drug-Induced Hyperglycaemia and Diabetes.

Similar Documents

Drug-induced hypoglycaemia: an update.

Drug-induced thrombocytopenia: an updated systematic review, 2012.

Preventability of drug-related harms - part II: proposed criteria, based on frameworks that classify adverse drug reactions.

Drug-induced thrombocytopenia: an updated systematic review, 2008.

Drug-induced thrombosis: an update.

Primary hepatocytes as a model to analyze species-specific toxicity and drug metabolism.

Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review.

Comment on: 'Drug-Induced Hyperglycaemia and Diabetes'.

The human microbiome and therapeutics.

Drug-Induced Hyperglycaemia and Diabetes.