NDLI: Daylight photodynamic therapy with methyl-aminolevulinate for the treatment of actinic cheilitis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fai, Dario Romanello, Eugenio Brumana, Marta Benedetta Fai, Carlotta Vena, Gino Antonio Cassano, Nicoletta Piaserico, Stefano
Description	Country affiliation: Italy Author Affiliation: Fai D ( Phototherapy Unit-Dermatology Service, AUSL LECCE, Salento, Italy.); Romanello E ( Phototherapy Unit-Dermatology Service, AUSL LECCE, Salento, Italy.); Brumana MB ( Dermatology Unit, Department of Dermatology, University of Padua, Padua, Italy.); Fai C ( Phototherapy Unit-Dermatology Service, AUSL LECCE, Salento, Italy.); Vena GA ( Dermatology and Venereology Private Practice, Bari and Barletta, Italy.); Cassano N ( Dermatology and Venereology Private Practice, Bari and Barletta, Italy.); Piaserico S ( Dermatology Unit, Department of Dermatology, University of Padua, Padua, Italy.)
Abstract	Actinic cheilitis (AC) is a common premalignant condition that requires an effective treatment to reduce the risk of malignant transformation. Photodynamic therapy (PDT) has been recently added to the armamentarium available for AC treatment. Daylight PDT (D-PDT) is a novel PDT modality in which the activation of the topical photosensitizer is induced by the exposure to natural daylight instead of artificial light sources without preliminary occlusion. This simplified procedure was found to be more tolerated as compared to conventional PDT. We report our preliminary experience on the use of D-PDT using methyl-aminolevulinate cream in 10 patients with refractory AC of the lower lip. Patients received two consecutive D-PDT sessions with an interval of 7-14 days. At 3 months after therapy, a complete response was observed in seven patients, with sustained results in five patients over an observational period of 6-12 months. Treatment was well tolerated.
File Format	HTM / HTML
ISSN	13960296
Issue Number	6
Volume Number	28
e-ISSN	15298019
Journal	Dermatologic Therapy
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-11-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Dermatology Aminolevulinic Acid Analogs & Derivatives Cheilitis Drug Therapy Light Photochemotherapy Methods Photosensitizing Agents Administration & Dosage Administration, Cutaneous Aged Aged, 80 And Over Adverse Effects Diagnosis Female Humans Male Middle Aged Remission Induction Retrospective Studies Skin Cream Time Factors Treatment Outcome Journal Article
Content Type	Text
Resource Type	Article
Subject	Dermatology

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