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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Leuppi, Jörg D. |
| Description | Country affiliation: Switzerland Author Affiliation: Leuppi JD ( Medical University Clinic, Canton Hospital Baselland, Liestal, Switzerland.) |
| Abstract | PURPOSE OF REVIEW: This review describes different bronchoprovocation tests and their merits in diagnosing asthma. RECENT FINDINGS: A new indirect challenge test using dry powder mannitol has been made available and has been systematically validated and tested in different populations. SUMMARY: Airway hyperresponsiveness (AHR) is a characteristic feature of asthma, and its measurement using direct inhalation challenges, particularly with inhaled methacholine or histamine, or indirect challenges using stimuli such as exercise, dry air hyperpnea, distilled water, hypertonic saline and mannitol, and the pharmacological agent adenosine monophosphate is important in establishing a correct diagnosis. Direct challenge tests are sensitive and have a high negative predictive value to exclude asthma. This is particularly true in excluding asthma as a diagnosis in patients with symptoms that suggest asthma, but are caused by another condition. Indirect AHR correlates better with eosinophilic airway inflammation. Therefore, indirect challenge tests are seen as more specific. A newer indirect challenge test that uses a kit containing prepacked capsules of dry powder mannitol in different doses is safe and efficient to use. Indirect challenge tests are superior to direct challenge tests to confirm the presence of asthma. |
| File Format | HTM / HTML |
| ISSN | 10705287 |
| Issue Number | 1 |
| Volume Number | 20 |
| e-ISSN | 15316971 |
| Journal | Current Opinion in Pulmonary Medicine |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2014-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pulmonary Medicine Asthma Chemically Induced Diagnosis Bronchial Provocation Tests Methods Histamine Adverse Effects Humans Mannitol Methacholine Chloride Respiratory Hypersensitivity Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine |
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