NDLI: Should mild cognitive impairment be subtyped?

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Should mild cognitive impairment be subtyped?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hughes, Tiffany F. Snitz, Beth E. Ganguli, Mary
Description	Country affiliation: United States Author Affiliation: Hughes TF ( Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.)
Abstract	PURPOSE OF REVIEW: To review evidence on the validity and utility of recent approaches to subtyping late-life mild cognitive impairment. RECENT FINDINGS: There is growing evidence that amnestic mild cognitive impairment is associated with biomarkers for Alzheimer's disease, while nonamnestic mild cognitive impairment maps more closely to cerebrovascular disease. The former is more likely to progress to dementia than the latter. Mild impairment in multiple cognitive domains appears to represent a more advanced disease state than single-domain impairment, and is more likely to progress to dementia. The cognitive subtypes have imprecise boundaries and have limited ecological validity. Approaches to subtyping that also incorporate biomarkers increase diagnostic specificity and have greater predictive value. However, these approaches have yet to be validated outside specialized memory clinic populations. SUMMARY: Mild cognitive impairment as currently defined is still etiologically and prognostically heterogeneous, particularly outside specialty clinical settings. The objective of further subtyping is to delineate subgroups that are more clinically homogeneous. The current cognitive subtypes have some validity and utility but additional approaches should be explored so as to enhance these properties.
File Format	HTM / HTML
ISSN	09517367
e-ISSN	14736578
DOI	10.1097/YCO.0b013e328344696b
Journal	Current Opinion in Psychiatry
Issue Number	3
Volume Number	24
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2011-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Psychiatry Aging Psychology Cognition Disorders Classification Memory Disorders Diagnosis Neuropsychological Tests Reproducibility Of Results Severity Of Illness Index Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Psychiatry and Mental Health

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