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Treatment options for patients with recurrent or metastatic squamous cell carcinoma of the head and neck, who progress after platinum-based chemotherapy.

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Active surveillance for prostate cancer: past, present and future.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Singer, Eric A. Kaushal, Aradhana Turkbey, Baris Couvillon, Anna Pinto, Peter A. Parnes, Howard L.
Description	Country affiliation: United States Author Affiliation: Singer EA ( Urologic Oncology Branch, Center for Cancer Research, Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, United States.)
Abstract	PURPOSE OF REVIEW: This article reviews recent developments in the use of active surveillance for localized prostate cancer. RECENT FINDINGS: The treatment of localized prostate cancer continues to be a major challenge for urologic oncologists. Screening with prostate-specific antigen has resulted in increased numbers of low-risk prostate cancers being detected. Aggressive whole-gland therapy with surgery, or radiation therapy is associated with potentially life-altering treatment-related side effects such as urinary incontinence, bowel toxicity and erectile dysfunction. The goal of active surveillance is to avoid or delay the adverse events associated with prostate cancer therapy while still allowing for curative intervention in the future, if needed. SUMMARY: Active surveillance is a reasonable treatment option for many men with low-risk, and some men with intermediate-risk, prostate cancer. Additional research is needed to determine the optimal active surveillance inclusion criteria, monitoring schedule, and treatment triggers. It is hoped that advances in prostate imaging, biomarkers, and focal therapy will foster greater use of active surveillance in appropriately selected men to optimize quality-of-life without compromising cancer outcomes.
File Format	HTM / HTML
ISSN	10408746
Issue Number	3
Volume Number	24
e-ISSN	1531703X
Journal	Current Opinion in Oncology
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2012-05-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Oncology Population Surveillance Prostate-specific Antigen Blood Prostatic Neoplasms Diagnosis Therapy Quality Of Life Watchful Waiting Tumor Markers, Biological Early Diagnosis Erectile Dysfunction Etiology Humans Male Patient Selection Prostatectomy Adverse Effects Immunology Radiotherapy Surgery Journal Article Research Support, N.i.h., Intramural Review
Alternative Title	Active surveillance for prostate cancer: past, present and future
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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