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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pirker, Robert |
| Description | Country affiliation: Austria Author Affiliation: Pirker R ( Department of Medicine I, Medical University of Vienna, Vienna, Austria.) |
| Abstract | PURPOSE OF REVIEW: Patients with epidermal growth factor receptor (EGFR) mutation-positive nonsmall cell lung cancer (NSCLC) develop resistance during therapy with EGFR tyrosine kinase inhibitors (TKIs). In about half of the patients, this resistance is because of the emergence of the T790M mutation. Third-generation TKIs are active against EGFR-activating mutations and the T790M resistance mutation and have only limited efficacy against wild-type EGFR. Here we review the current status of the clinical development of these novel TKIs. RECENT FINDINGS: Third-generation TKIs in clinical development include osimertinib, rociletinib, and HM61713. Osimertinib and rociletinib have shown clinical efficacy in phase I/II trials in patients who had acquired resistance to first- or second-generation TKIs. Both TKIs are currently further evaluated in phase III trials as first-line or second-line therapy in patients with advanced EGFR mutation-positive NSCLC. HM61713 is in early clinical development. SUMMARY: Third-generation EGFR TKIs have shown activity in patients with acquired resistance to first- and second-generation EGFR TKIs and may further improve clinical outcome in patients with advanced EGFR mutation-positive NSCLC. |
| File Format | HTM / HTML |
| ISSN | 10408746 |
| Issue Number | 2 |
| Volume Number | 28 |
| e-ISSN | 1531703X |
| Journal | Current Opinion in Oncology |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2016-03-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Oncology Antineoplastic Agents Therapeutic Use Antineoplastic Combined Chemotherapy Protocols Carcinoma, Non-small-cell Lung Drug Therapy Lung Neoplasms Protein Kinase Inhibitors Receptor, Epidermal Growth Factor Antagonists & Inhibitors Acrylamides Mortality Drug Resistance, Neoplasm Humans Mutation Genetics Piperazines Pyrimidines Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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