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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hwang, Dae-Sik Lee, Jin-Seon Lee, Kyun-Woo Rhee, Jae-Sung Han, Jeonghoon Lee, Jehee Park, Gyung Soo Lee, Young-Mi Lee, Jae-Seong |
| Description | Country affiliation: South Korea Author Affiliation: Hwang DS ( Department of Molecular and Environmental Bioscience, Graduate School, Hanyang University, Seoul 133-791, South Korea.) |
| Abstract | Ecdysteroids are steroid hormones that play an important role in development, growth, molting of larva, and reproduction in the Arthropoda. The effect of ecdysteroids is mediated by its binding to ecdysteroid receptor (EcR). To investigate the role of EcR during development and the effect to environmental stressors on EcR expression in a copepod, we isolated and characterized cDNA and 5'-promoter region of the Tigriopus japonicus EcR (TJ-EcR), and studied mRNA expression pattern. The full-length TJ-EcR cDNA sequence was 1962bp in length and the open reading frame encoded 546 amino acids. The deduced TJ-EcR protein contained well-conserved DNA-binding domain and ligand-binding domain. Phylogenetic analysis revealed that TJ-EcR was clustered with the EcR of other crustaceans. TJ-EcR mRNA was expressed in a developmental stage-specific manner: high in early developmental stages and low in the adult stage. Significantly elevated expression of the TJ-EcR gene in adults was detected at hypersalinity (42ppt) and high temperature (35 degrees C) condition. The 5'-flanking region of TJ-EcR gene contains heat shock protein 70 response elements, implying that the environmental stressors may affect its expression via the stress-sensor. In addition, bisphenol A (100microg/L) repressed TJ-EcR expression. Our results suggest that TJ-EcR could be a biomarker for the monitoring of the impact of environmental stressors in copepods. |
| File Format | HTM / HTML |
| ISSN | 15320456 |
| Issue Number | 3 |
| Volume Number | 151 |
| Journal | Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-04-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Discipline Pharmacology Copepoda Metabolism Receptors, Steroid 5' Flanking Region Genetics Amino Acid Sequence Animals Base Sequence Benzhydryl Compounds Cloning, Molecular Drug Effects Dna, Complementary Endocrine Disruptors Toxicity Gene Expression Ligands Molecular Sequence Data Open Reading Frames Phenols Phylogeny Promoter Regions, Genetic Protein Structure, Tertiary Rna, Messenger Salinity Sequence Analysis, Dna Sequence Homology, Amino Acid Stress, Physiological Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Physiology Health, Toxicology and Mutagenesis Medicine Aquatic Science Biochemistry Toxicology Animal Science and Zoology |
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