NDLI: Expression of two cytochrome P450 aromatase genes is regulated by endocrine disrupting chemicals in rare minnow Gobiocypris rarus juveniles.

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Expression of two cytochrome P450 aromatase genes is regulated by endocrine disrupting chemicals in rare minnow Gobiocypris rarus juveniles.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Jingjing Liu, Xiaolin Wang, Houpeng Wu, Tingting Hu, Xiaoqi Qin, Fang Wang, Zaizhao
Description	Country affiliation: China Author Affiliation: Wang J ( College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, China.)
Abstract	To elucidate the effects of endocrine disrupting chemicals (EDCs) on aromatase, the rare minnow ovarian and brain P450 aromatase (cyp19a1a and cyp19a1b) cDNA and their 5'-flanking regions were isolated and characterized. RT-PCR analysis revealed that the rare minnow cyp19a1a mRNA was predominantly expressed in ovary while cyp19a1b was predominantly expressed in brain. Sequences for binding sites of steroidogenic factor-1, peroxisome proliferators-activated receptor, aryl hydrocarbon receptor, CCAAT/enhancer binding protein, estrogen responsive element, glucocorticoid responsive element, and retinoic acid receptor were identified on promoter regions of cyp19a1 genes. The influence of several EDCs on the transcript abundance of cyp19a1a and cyp19a1b was investigated in rare minnow juveniles. Clofibrate did not influence the expression of either cyp19a1 genes. Exposure to 1nM ethinylestradiol (EE2) for 3days significantly downregulated the expression of cyp19a1a gene, however 0.1 and 1 nM EE2 significantly increased the gene expression of cyp19a1b. Exposure to 100 and 1000 nM 4-nonylphenol (NP) significantly suppressed the cyp19a1a expression, but it had no effect on the expression of cyp19a1b gene. Bisphenol A (BPA) strongly suppressed the cyp19a1b gene expression from 0.1 to 10 nM and significantly suppressed the gene expression of cyp19a1a only at 10 nM. These results indicate that EDCs may influence the expression of cyp19a1 genes through differential transcriptional modulation in rare minnow juveniles.
File Format	HTM / HTML
ISSN	15320456
Issue Number	3
Volume Number	152
Journal	Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2010-09-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Discipline Pharmacology Aromatase Genetics Cyprinidae Metabolism Endocrine Disruptors Toxicity Gene Expression Regulation, Enzymologic Drug Effects Water Pollutants, Chemical Animals Benzhydryl Compounds Brain Clofibrate Growth & Development Ethinyl Estradiol Female Male Molecular Sequence Data Ovary Phenols Rna, Messenger Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology Health, Toxicology and Mutagenesis Medicine Aquatic Science Biochemistry Toxicology Animal Science and Zoology

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Molecular characterization of estrogen receptor genes in Gobiocypris rarus and their expression upon endocrine disrupting chemicals exposure in juveniles.

Molecular cloning of Foxl2 gene and the effects of endocrine-disrupting chemicals on its mRNA level in rare minnow, Gobiocypris rarus.

Effects of bisphenol A on lipid metabolism in rare minnow Gobiocypris rarus.

Adsorption and desorption behaviors of selected endocrine disrupting chemicals in simulated gastrointestinal fluids.

Molecular cloning of Foxl2 gene and the effects of endocrine-disrupting chemicals on its mRNA level in rare minnow, Gobiocypris rarus

Endocrine disruption by di-(2-ethylhexyl)-phthalate in Chinese rare minnow (Gobiocypris rarus).

Effects of 17 -ethinylestradiol and bisphenol A on steroidogenic messenger ribonucleic acid levels in the rare minnow gonads.

The impact of long term exposure to phthalic acid esters on reproduction in Chinese rare minnow (Gobiocypris rarus).

Comparative responses to endocrine disrupting compounds in early life stages of Atlantic salmon, Salmo salar.

Expression of two cytochrome P450 aromatase genes is regulated by endocrine disrupting chemicals in rare minnow Gobiocypris rarus juveniles.

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Molecular characterization of estrogen receptor genes in Gobiocypris rarus and their expression upon endocrine disrupting chemicals exposure in juveniles.

Molecular cloning of Foxl2 gene and the effects of endocrine-disrupting chemicals on its mRNA level in rare minnow, Gobiocypris rarus.

Effects of bisphenol A on lipid metabolism in rare minnow Gobiocypris rarus.

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Molecular cloning of Foxl2 gene and the effects of endocrine-disrupting chemicals on its mRNA level in rare minnow, Gobiocypris rarus

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Expression of two cytochrome P450 aromatase genes is regulated by endocrine disrupting chemicals in rare minnow Gobiocypris rarus juveniles.