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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bakke, Marit Jørgensen Horsberg, Tor Einar |
| Description | Country affiliation: Norway Author Affiliation: Bakke MJ ( Department of Pharmacology and Toxicology, Norwegian School of Veterinary Science, Oslo, Norway. marit.bakke@nvh.no) |
| Abstract | The disposition of STX in Atlantic salmon (Salmo salar) and Atlantic cod (Gadus morhua) was studied after intraperitoneal (IP) injection (5 microg STX/kg bm and 3.43 microg (3)H-STXeq/kg bw respectively), intravenous (IV) injection (5 microg STX/kg bm, only salmon) and waterborne exposure (50 microg STXeq/L, only salmon). Plasma concentrations in salmon were quantified using a receptor binding assay and cod tissues were analyzed using scintillation counting of tissue extracts and autoradiography of whole fish slices. The estimated elimination half-life (T(1/2)) after IV administration of STX in salmon was 102.6 min. The volume of distribution (Vz) was observed to be 467.2 mL/kg and the total body clearance (Cl(T)) was 3.2 mL/min/kg. Waterborne exposure clearly showed that salmon absorbed PSP toxins directly from the water. In cod, (3)H-STX was observed in gills, muscle, brain, liver and posterior kidney from 30 to 480 min. The lowest concentrations of (3)H-STX were found in brain and muscle, whereas posterior kidney contained the majority of the toxin. Autoradiograms confirmed the high levels of (3)H-STX in the kidneys, indicating that renal excretion was the main elimination route. Buildup of harmful levels in edible tissue is not very likely due to the low concentrations accumulated in muscle tissue and rapid excretion. |
| File Format | HTM / HTML |
| ISSN | 15320456 |
| Issue Number | 4 |
| Volume Number | 152 |
| Journal | Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Discipline Pharmacology Gadus Morhua Metabolism Poisons Pharmacokinetics Salmo Salar Saxitoxin Animals Autoradiography Toxicity Radionuclide Imaging Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Physiology Health, Toxicology and Mutagenesis Medicine Aquatic Science Biochemistry Toxicology Animal Science and Zoology |
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