NDLI: Hepatitis B virus and hepatitis C virus co-infection: a therapeutic challenge. (Journal: Clinics and Research in Hepatology and Gastroenterology Volume: 37 Issue: 1)

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Hepatitis B virus and hepatitis C virus co-infection: a therapeutic challenge. (Journal: Clinics and Research in Hepatology and Gastroenterology Volume: 37 Issue: 1)

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hamzaoui, Lamine El Bouchtili, Souheil Siai, Karima Mahmoudi, Moufida Azzouz, Mohamed Msaddak
Description	Country affiliation: Tunisia Author Affiliation: Hamzaoui L ( Gastroenterology department, Mohamed Tahar Maamouri Hospital, Nabeul, Tunisia. lamine015@yahoo.fr)
Abstract	Hepatitis B virus and hepatitis C virus are the two most common causes of chronic liver disease in the world. Dual infection with hepatitis B virus and hepatitis C virus, whose prevalence is underestimated, is characterized by a more severe liver injury, a higher probability of liver cirrhosis and a higher incidence of hepatocellular carcinoma. Treatment of these patients represents a therapeutic challenge. We report the case of an hepatitis B virus-hepatitis C virus co-infected patient, which particularly illustrates the interactions between these two viruses and therapeutic problems caused by the dual infection. HCV was initially dominant, which indicated a combination therapy by pegylated interferon and ribavirin. This treatment was associated with an early virological response of the HCV but an increase of HBV DNA occurred, requiring the use of a nucleoside analogue. A good response was obtained for the HBV but a relapse of HCV was noted, posing a problem for therapeutic decision.
File Format	HTM / HTML
ISSN	22107401
Issue Number	1
Volume Number	37
e-ISSN	2210741X
Journal	Clinics and Research in Hepatology and Gastroenterology
Language	English
Publisher	Elsevier
Publisher Date	2013-02-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Hepatology Discipline Gastroenterology Antiviral Agents Therapeutic Use Guanine Analogs & Derivatives Hepatitis B, Chronic Complications Drug Therapy Hepatitis C, Chronic Interferon-alpha Polyethylene Glycols Ribavirin Adult Drug Therapy, Combination Virology Humans Male Recombinant Proteins Recurrence Case Reports Journal Article
Content Type	Text
Resource Type	Case study Article
Subject	Hepatology Gastroenterology

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