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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sun, Huiling Hou, Jinjun Shi, Wenbin Zhang, Lei |
| Description | Country affiliation: China Author Affiliation: Sun H ( Department of Life Sciences, Nanjing Normal University, Nanjing 210046, Jiangsu, China.); Hou J ( Clinical Laboratory, Mother and Child Health Care Hospital of Qixia District, Nanjing, Nanjing 210028, Jiangsu, China); Shi W ( Clinical Laboratory, Nanjing Traditional Chinese Medical Hospital, Nanjing 210001, Jiangsu, China.); Zhang L ( Department of Orthopaedics, Lanxi People's Hospital, Jinhua, 321100 Zhejiang, China.) |
| Abstract | BACKGROUND: Emerging published data on the association between single nucleotide polymorphisms (SNPs) in the estrogen receptor 1 (ESR1) gene and cancer susceptibility are inconsistent. This review and meta-analysis is performed to derive a more precise evaluation of this relationship. METHODS: The literature search of PubMed, Embase, Web of Science and CNKI databases was conducted from their inception through June 2014. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association. RESULTS: Twenty-two literatures were enrolled in this meta-analysis. The results indicated that ESR1 rs1801132 (C>G) was associated with cancer risk in Caucasian populations. However, the results of stratified analysis by cancer type and source of controls indicated that no significant association was found. Furthermore, rs2077647 (A>G) was only associated with an increased risk of hepatocellular carcinoma, but was an adverse effect on cancer risk in Caucasian populations. CONCLUSIONS: This present meta-analysis indicated that rs1801132 (C>G) and rs2077647 (A>G) may be protective factors in Caucasian populations. Meanwhile, rs2077647 (A>G) may be closely related with hepatocellular carcinoma. |
| File Format | HTM / HTML |
| ISSN | 22107401 |
| Issue Number | 1 |
| Volume Number | 39 |
| e-ISSN | 2210741X |
| Journal | Clinics and Research in Hepatology and Gastroenterology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-02-01 |
| Publisher Place | France |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Hepatology Discipline Gastroenterology Carcinoma, Hepatocellular Genetics Estrogen Receptor Alpha Liver Neoplasms Epidemiology Genetic Variation Humans Risk Journal Article Meta-analysis Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hepatology Gastroenterology |
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