NDLI: Standard therapy with opioids in chronic pain management : ORTIBER study.

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Standard therapy with opioids in chronic pain management : ORTIBER study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gatti, Antonio Reale, Carlo Occhioni, Roberto Luzi, Marta Canneti, Alessandra De Polo, Claudia Gubernari, Martina Mammucari, Massimo Fabrizio Sabato, Alessandro
Spatial Coverage	Italy
Description	Country affiliation: Italy Author Affiliation: Gatti A ( University of Tor Vergata, Anaesthesiology and Intensive Care Medicine Department, Rome, Italy. Antonio.gatti@ptvonline.it)
Abstract	OBJECTIVE: Moderate to severe pain is commonly experienced by cancer and non-cancer patients. Although opioids are generally the most important drugs in chronic pain management, their use in Italy remains low. We designed a prospective open trial to assess the efficacy and safety of a standard therapy clinically available for a large range of patients. METHODS: A total of 172 consecutive patients (89 women and 83 men) with chronic pain (daily mean visual analogue scale (VAS) score > 4) that was not adequately managed by their existing pain regimen were enrolled to receive an immediate release (IR) dose of morphine: 30 mg/day (opioid-naive patients) or 60 mg/day (non-naive patients) for 5 days. After this period (start therapy), all patients were switched to slow release (SR) opioid therapy for 30 days (steady therapy). Each breakthrough pain (BTP) episode was treated with a single dose of IR morphine (20% of the daily dose) during all study periods. RESULTS: Daily VAS score was reduced from 7.4 +/- 1.3 at baseline to 3.8 +/- 1.5 (p < 0.0001) after 30 days of steady therapy in cancer and non-cancer patients. Fewer patients reported BTP events by study end (55% of patients with BTP at basal time had no BTP at last follow up), and the number of daily BTP events experienced by patients was reduced by therapy to 1-2 per day in 75% of patients reporting BTP. Further, the time delay to reach pain relief following administration of a rescue dose of IR morphine was 15 minutes or less in 52.1% of patients at study end. The standard therapy was well tolerated and fewer adverse effects were recorded at the end of the study period compared with baseline, with the exception of constipation, which showed a moderate increase (from 18.2% to 25.0%). CONCLUSION: Start therapy with IR morphine followed by conversion to SR opioid therapy could be implemented as a standard therapy to manage moderate to severe chronic pain in patients with cancer or non-cancer pain. ORamorph in TIBER study (ORTIBER).
File Format	HTM / HTML
ISSN	11732563
Issue Number	Suppl 1
Volume Number	29
e-ISSN	11791918
Journal	Clinical Drug Investigation
Language	English
Publisher	Springer
Publisher Date	2009-01-01
Publisher Place	New Zealand (Aotearoa)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Analgesics, Opioid Administration & Dosage Delayed-action Preparations Morphine Pain Drug Therapy Adult Aged Aged, 80 And Over Adverse Effects Chronic Disease Female Humans Italy Male Middle Aged Clinical Trial Journal Article Multicenter Study
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical)

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