NDLI: Teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw in an elderly Japanese woman with severe osteoporosis.

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Teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw in an elderly Japanese woman with severe osteoporosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Iwamoto, Jun Yago, Kaori Sato, Yoshihiro Matsumoto, Hideo
Spatial Coverage	Japan
Description	Country affiliation: Japan Author Affiliation: Iwamoto J ( Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan. jiwamoto@a8.keio.jp)
Abstract	We report on the case of a severely osteoporotic elderly Japanese woman with bisphosphonate-associated osteonecrosis of the jaw (ONJ), who was treated successfully with teriparatide. A 79-year-old woman with severe osteoporosis and bisphosphonate-associated ONJ was treated with teriparatide after debridement of the necrotic tissue in the jaw bone. Computed tomography (CT) images revealed the bone defect in the mandible after debridement of the necrotic tissue associated with ONJ. According to the attending dentist, the ONJ healed after 2 months of therapy. After 3 months of treatment, a robust increase in the serum level of the bone formation marker, serum intact procollagen type 1 N-terminal propeptide, was noted and a repeat CT revealed improvement of the bone defect of the mandible. These results suggest the beneficial effects of teriparatide therapy in the severely osteoporotic elderly woman with ONJ.
File Format	HTM / HTML
ISSN	11732563
Issue Number	8
Volume Number	32
e-ISSN	11791918
Journal	Clinical Drug Investigation
Language	English
Publisher	Springer
Publisher Date	2012-08-01
Publisher Place	New Zealand (Aotearoa)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Diphosphonates Adverse Effects Jaw Diseases Drug Therapy Osteoporosis Teriparatide Therapeutic Use Aged Bone Density Female Humans Japan Chemically Induced Tomography, X-ray Computed Case Reports Journal Article
Content Type	Text
Resource Type	Case study Article
Subject	Pharmacology (medical)

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