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Characteristics and clinical implications of the pharmacokinetic profile of ibuprofen in patients with knee osteoarthritis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gallelli, L. Galasso, O. Urzino, A. Saccà, S. Falcone, D. Palleria, C. Longo, P. Corigliano, A. Terracciano, R. Savino, R. Gasparini, G. De Sarro, G. Southworth, S. R.
Description	Country affiliation: Italy Author Affiliation: Gallelli L ( Clinical Pharmacology Unit, Department of Health Science, School of Medicine, University of Catanzaro, Mater Domini University Hospital, Viale Europa-Germaneto, Catanzaro, Italy. gallelli@unicz.it)
Abstract	BACKGROUND AND OBJECTIVE: Ibuprofen is a non-selective cyclo-oxygenase (COX)-1/COX-2 inhibitor used to treat pain conditions and inflammation. Limited data have been published concerning the pharmacokinetic profile and clinical effects of ibuprofen in patients with osteoarthritis (OA). In this paper we compared the pharmacokinetic and clinical profile of ibuprofen (at a dosage of from 800 mg/day to 1800 mg/day) administered in patients affected by severe knee OA. METHODS: Ibuprofen was administered for 7 days to patients who were scheduled to undergo knee arthroplasty due to OA. After 7 days, the ibuprofen concentration in plasma and synovial fluid was measured through both high-performance liquid chromatography (HPLC)-UV and gas chromatography-mass spectroscopy (GC/MS), while clinical effects were evaluated through both visual analogue scale (VAS) and Western Ontario and McMaster Universities (WOMAC) scores. The Naranjo scale and the WHO causality assessment scale were used for estimating the probability of adverse drug reactions (ADRs). The severity of ADRs was assessed by the modified Hartwig and Siegel scale. RESULTS: Ibuprofen showed a dose-dependent diffusion in both plasma and synovial fluid, which was related to the reduction of pain intensity and improvement of health status, without the development of ADRs. CONCLUSION: Ibuprofen at higher dosages can be expected to provide better control of OA symptoms as a result of higher tissue distribution.
File Format	HTM / HTML
ISSN	11732563
Issue Number	12
Volume Number	32
e-ISSN	11791918
Journal	Clinical Drug Investigation
Language	English
Publisher	Springer
Publisher Date	2012-12-01
Publisher Place	New Zealand (Aotearoa)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Anti-inflammatory Agents, Non-steroidal Pharmacokinetics Ibuprofen Osteoarthritis, Knee Drug Therapy Aged Administration & Dosage Adverse Effects Chromatography, High Pressure Liquid Dose-response Relationship, Drug Female Gas Chromatography-mass Spectrometry Humans Male Middle Aged Pathology Pain Etiology Pain Measurement Severity Of Illness Index Synovial Fluid Metabolism Treatment Outcome Comparative Study Journal Article Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical)

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