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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Scott, Lesley J. |
| Description | Country affiliation: New Zealand Author Affiliation: Scott LJ ( Springer, Private Bag 65901, Mairangi Bay, Auckland 0754, New Zealand. demail@springer.com) |
| Abstract | Oral teneligliptin [Teneglucon® (Argentina)], a dipeptidyl peptidase-4 inhibitor, is indicated for the treatment of adults with type 2 diabetes (T2DM). This article reviews the pharmacology, therapeutic efficacy and tolerability of teneligliptin in the treatment of adults with T2DM. In 12- or 16-week, placebo-controlled phase 2 and 3 trials, oral teneligliptin 20 or 40 mg once daily, as monotherapy or in combination with metformin, glimepiride or pioglitazone improved glycaemic control, including in patients with end-stage renal disease, and was generally well tolerated. Most treatment-emergent adverse events were of mild intensity and relatively few patients discontinued treatment because of these events. Improvements in glycaemic control observed in short-term trials were maintained at 52 weeks in extension phases of these trials and in 52-week interventional studies, with no new safety concerns identified during this period. In the absence of direct head-to-head clinical trials, the position of teneligliptin relative to other antidiabetic agents in the management of T2DM remains to be determined. In the meantime, teneligliptin is a useful treatment option for adults with T2DM who have not responded adequately to diet and exercise regimens, or the addition of antidiabetic drugs. |
| File Format | HTM / HTML |
| ISSN | 11732563 |
| Issue Number | 11 |
| Volume Number | 35 |
| e-ISSN | 11791918 |
| Journal | Clinical Drug Investigation |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2015-11-01 |
| Publisher Place | New Zealand (Aotearoa) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Diabetes Mellitus, Type 2 Drug Therapy Pyrazoles Therapeutic Use Thiazolidines Adult Dipeptidyl-peptidase Iv Inhibitors Adverse Effects Pharmacokinetics Pharmacology Drug Therapy, Combination Humans Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) |
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