NDLI: In vivo mononuclear cell tracking using superparamagnetic particles of iron oxide: feasibility and safety in humans.

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In vivo mononuclear cell tracking using superparamagnetic particles of iron oxide: feasibility and safety in humans.

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Year: 2012 Volume: 5 Issue: 1

In vivo mononuclear cell tracking using superparamagnetic particles of iron oxide: feasibility and safety in humans.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Richards, Jennifer M. J. Shaw, Catherine A. Lang, Ninian N. Williams, Michelle C. Semple, Scott I. K. MacGillivray, Thomas J. Gray, Calum Crawford, Julie H. Alam, Shirjel R. Atkinson, Anne P. M. Forrest, Elaine K. Bienek, Carol Mills, Nicholas L. Burdess, Anne Dhaliwal, Kev Simpson, A. John Wallace, William A. Hill, Adam T. Roddie, P. Huw McKillop, Graham Connolly, Thomas A. Feuerstein, Giora Z. Barclay, G. Robin Turner, Marc L. Newby, David E.
Description	Country affiliation: United kingdom Author Affiliation: Richards JM ( Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom . jenny.richards@ed.ac.uk)
Abstract	BACKGROUND: Cell therapy is an emerging and exciting novel treatment option for cardiovascular disease that relies on the delivery of functional cells to their target site. Monitoring and tracking cells to ensure tissue delivery and engraftment is a critical step in establishing clinical and therapeutic efficacy. The study aims were (1) to develop a Good Manufacturing Practice-compliant method of labeling competent peripheral blood mononuclear cells with superparamagnetic particles of iron oxide (SPIO), and (2) to evaluate its potential for magnetic resonance cell tracking in humans. METHODS AND RESULTS: Peripheral blood mononuclear cells 1-5 × 10(9) were labeled with SPIO. SPIO-labeled cells had similar in vitro viability, migratory capacity, and pattern of cytokine release to unlabeled cells. After intramuscular administration, up to 10(8) SPIO-labeled cells were readily identifiable in vivo for at least 7 days using magnetic resonance imaging scanning. Using a phased-dosing study, we demonstrated that systemic delivery of up to 10(9) SPIO-labeled cells in humans is safe, and cells accumulating in the reticuloendothelial system were detectable on clinical magnetic resonance imaging. In a healthy volunteer model, a focus of cutaneous inflammation was induced in the thigh by intradermal injection of tuberculin. Intravenously delivered SPIO-labeled cells tracked to the inflamed skin and were detectable on magnetic resonance imaging. Prussian blue staining of skin biopsies confirmed iron-laden cells in the inflamed skin. CONCLUSIONS: Human peripheral blood mononuclear cells can be labeled with SPIO without affecting their viability or function. SPIO labeling for magnetic resonance cell tracking is a safe and feasible technique that has major potential for a range of cardiovascular applications including monitoring of cell therapies and tracking of inflammatory cells. Clinical Trial Registration- URL: http://www.clinicaltrials.gov; Unique identifier: NCT00972946, NCT01169935.
File Format	HTM / HTML
ISSN	19419651
e-ISSN	19420080
Journal	Circulation: Cardiovascular Imaging
Issue Number	4
Volume Number	5
Language	English
Publisher	American Heart Association
Publisher Date	2012-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Diagnostic Imaging Discipline Cardiology Cell Tracking Contrast Media Pharmacokinetics Dextrans Leukocytes, Mononuclear Metabolism Magnetic Resonance Imaging Cell Movement Drug Effects Chemistry Cytokines Feasibility Studies Image Processing, Computer-assisted Imaging, Three-dimensional Magnetite Nanoparticles Patient Safety Staining And Labeling Statistics, Nonparametric Tuberculin Test Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Cardiology and Cardiovascular Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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