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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ibrahim, Mohammad Prigol, Marina Hassan, Waseem Nogueira, Cristina W. Rocha, Joao B. T. |
| Description | Country affiliation: Brazil Author Affiliation: Ibrahim M ( Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.) |
| Abstract | Organoselenides have been documented as promising pharmacological agents against a number of diseases associated with oxidative stress. Here we have investigated, for the first time, the potential antioxidant activity of binaphthyl diselenide ((NapSe)(2); 50 mg kg(-1), p.o.) against the 2-nitropropane (2-NP)-induced hepatoxicity in rats, using different end points of toxicity (liver histopathology, plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatinine). In addition, in view of the association of oxidative stress with 2-NP exposure, hepatic lipid peroxidation, ascorbic acid levels, delta-aminolevulinate dehydratase (delta-ALA-D) and catalase (CAT) activities were evaluated. 2-NP caused an increase of AST, ALT and hepatic lipid peroxidation. 2-NP also caused hepatic histopathological alterations and delta-ALA-D inhibition. (NapSe)(2) (50 mg kg(-1)) prevented 2-NP-induced changes in plasmatic ALT and AST activities and also prevented changes in hepatic histology, delta-ALA-D and lipid peroxidation. Results presented here indicate that the protective mechanism of (NapSe)(2) against 2-NP hepatotoxicity is possibly linked to its antioxidant activity. |
| File Format | HTM / HTML |
| ISSN | 02636484 |
| Issue Number | 4 |
| Volume Number | 28 |
| e-ISSN | 10990844 |
| Journal | Cell Biochemistry and Function |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2010-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Cell Biology Discipline Biochemistry Antioxidants Pharmacology Drug-induced Liver Injury Prevention & Control Organoselenium Compounds Alanine Transaminase Metabolism Animals Chemistry Ascorbic Acid Aspartate Aminotransferases Catalase Pathology Creatinine Lipid Peroxidation Nitroparaffins Toxicity Oxidative Stress Porphobilinogen Synthase Propane Analogs & Derivatives Rats Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Biochemistry Clinical Biochemistry |
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