NDLI: Bone marrow-derived mesenchymal stem cells differentiation into tubular epithelial-like cells in vitro.

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Bone marrow-derived mesenchymal stem cells differentiation into tubular epithelial-like cells in vitro.

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Bone marrow-derived mesenchymal stem cells differentiation into tubular epithelial-like cells in vitro.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wan, Jian-Xin Zou, Zhen-Huan You, Dan-Yu Cui, Jiong Pan, Yang-Bin
Description	Country affiliation: China Author Affiliation: Wan JX ( Department of Nephrology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China. wanjianxincn@hotmail.com)
Abstract	The possibility of differentiating bone marrow-derived mesenchymal stem cells (BMSCs) into tubular epithelial-like cells is explored in vitro. Purified BMSCs from Sprague-Dawley rats were obtained by density gradient centrifugation. Third generation BMSCs were divided into six groups and were cultured under different conditions. The expression of alkaline phosphatase and cytokeratin (CK)-18 protein was detected through staining and immunocytochemistry, respectively, and the expression of E-cadherin proteins was recorded through immunofluorescence. Some cells in ischemia/reperfusion (I/R), all-trans retinoic acid (ATRA), epidermal growth factor (EGF) and bone morphogenetic protein-7 (BMP-7) groups turned positive, whereas the positive cells in the combined group significantly increased compared with the other groups. Compared with the control group, the positive expression rates of CK-18 in the I/R, ATRA, EGF, BMP-7 and the combined group were 11·50% ± 3·84%, 27·40% ± 2·70%, 29·60% ± 4·51%, 26·80% ± 5·00% and 44·00% ± 3·16%, respectively, and CK-18 mRNA expression in the combined group was obviously higher than that in the other groups (P < 0·01). Immunofluorescence detection showed that E-cadherin expression was not detectable in the control group, whereas the positive expression rates of E-cadherin in the I/R, ATRA, EGF, BMP-7 and the combined group were 6·75% ± 2·13%, 16·40% ± 2·69%, 18·25% ± 3·50%, 16·06% ± 2·00% and 30·26% ± 5·16%, respectively. The addition of ATRA, EGF and BMP-7 induces BMSCs differentiation into tubular epithelial-like cells in stimulated acute renal failure microenvironment in vitro.
File Format	HTM / HTML
ISSN	02636484
Issue Number	2
Volume Number	30
e-ISSN	10990844
Journal	Cell Biochemistry and Function
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-03-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cell Biology Discipline Biochemistry Bone Marrow Cells Cytology Cell Differentiation Epithelial Cells Mesenchymal Stromal Cells Animals Metabolism Bone Morphogenetic Protein 7 Cadherins Genetics Epidermal Growth Factor Keratin-18 Rats Rats, Sprague-dawley Tretinoin Journal Article
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Biochemistry Clinical Biochemistry

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