NDLI: Quorum sensing inhibitors: an overview.

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Year: 2013 Volume: 31 Issue: 1

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Quorum sensing inhibitors: an overview.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kalia, Vipin Chandra
Description	Country affiliation: India Author Affiliation: Kalia VC ( Microbial Biotechnology and Genomics, CSIR-Institute of Genomics and Integrative Biology (IGIB), Delhi University Campus, Mall Road, Delhi-110007, India. vckalia@igib.res.in)
Abstract	Excessive and indiscriminate use of antibiotics to treat bacterial infections has lead to the emergence of multiple drug resistant strains. Most infectious diseases are caused by bacteria which proliferate within quorum sensing (QS) mediated biofilms. Efforts to disrupt biofilms have enabled the identification of bioactive molecules produced by prokaryotes and eukaryotes. These molecules act primarily by quenching the QS system. The phenomenon is also termed as quorum quenching (QQ). In addition, synthetic compounds have also been found to be effective in QQ. This review focuses primarily on natural and synthetic quorum sensing inhibitors (QSIs) with the potential for treating bacterial infections. It has been opined that the most versatile prokaryotes to produce QSI are likely to be those, which are generally regarded as safe. Among the eukaryotes, certain legumes and traditional medicinal plants are likely to act as QSIs. Such findings are likely to lead to efficient treatments with much lower doses of drugs especially antibiotics than required at present.
File Format	HTM / HTML
ISSN	07349750
Issue Number	2
Volume Number	31
e-ISSN	18731899
Journal	Biotechnology Advances
Language	English
Publisher	Elsevier
Publisher Date	2013-03-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biotechnology Anti-bacterial Agents Chemistry Pharmacology Bacterial Physiological Phenomena Quorum Sensing Drug Effects Acyl-butyrolactones Animals Isolation & Purification Aquaculture Aquatic Organisms Metabolism Microbiology Bacteria Pathogenicity Bacterial Proteins Biofilms Host-pathogen Interactions Humans Plants Repressor Proteins Trans-activators Waste Water Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Bioengineering Applied Microbiology and Biotechnology Biotechnology

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