NDLI: Effect of BMP-2 and BMP-7 homodimers and a mixture of BMP-2/BMP-7 homodimers on osteoblast adhesion and growth following culture on a collagen scaffold.

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Effect of BMP-2 and BMP-7 homodimers and a mixture of BMP-2/BMP-7 homodimers on osteoblast adhesion and growth following culture on a collagen scaffold.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Laflamme, Claude Rouabhia, Mahmoud
Description	Country affiliation: Canada Author Affiliation: Laflamme C ( Groupe de recherche en écologie buccale, Faculté de médecine dentaire, Université Laval, Québec City, Québec G1K 7P4, Canada.)
Abstract	In the present study, we studied the involvement of BMP-2 and BMP-7 as homodimers and as a mixture of homodimers in bone regeneration using an engineered bone model. The engineered bone model consisted of a collagen scaffold populated with osteoblasts that acted as a carrier for the BMPs. BMP-2, BMP-7 and a mixture of BMP-2/BMP-7 were used at final concentrations of 10 and 100 ng ml(-1). Osteoblasts seeded onto a collagen scaffold were cultured for 24 h before being stimulated with the BMPs. Four days later, osteoblast adhesion to and growth on the scaffold were assessed. Osteocalcin, IL-6, metalloproteinase (MMP-2 and MMP-9) and protease inhibitor (TIMP-1 and TIMP-2) mRNA and protein levels were measured. Our results showed that the BMP-2, BMP-7 and a mixture of BMP-2/BMP-7 all promoted osteoblast growth on the collagen scaffold, with the mixture of BMP-2/BMP-7 enhancing the most growth. BMP-2 and the mixture of BMP-2/BMP-7 enhanced osteocalcin (an osteoblast differentiation marker) mRNA expression and protein secretion, likely via the IL-6 pathway given that IL-6 secretion was upregulated by BMP-7 and a mixture of BMP-2/BMP-7. BMPs promote extracellular matrix production by inhibiting MMP-2 mRNA and increasing TIMP-1 and TIMP-2 mRNA expressions and protein secretions. BMP-2, BMP-7 and the mixture of BMP-2/BMP-7 could promote bone regeneration via different mechanisms involving IL-6 and MMP inhibitors.
File Format	HTM / HTML
ISSN	17486041
e-ISSN	1748605X
Journal	Biomedical Materials
Issue Number	1
Volume Number	3
Language	English
Publisher	IOP Publishing
Publisher Date	2008-03-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Biomedical Engineering Bone Morphogenetic Proteins Administration & Dosage Collagen Chemistry Osteoblasts Physiology Tissue Engineering Transforming Growth Factor Beta Bone Morphogenetic Protein 2 Bone Morphogenetic Protein 7 Cell Adhesion Drug Effects Cell Culture Techniques Cell Line Cell Proliferation Dimerization Dose-response Relationship, Drug Drug Combinations Materials Testing Cytology Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Chemistry Business and International Management Mechanics of Materials Biomaterials Bioengineering Biomedical Engineering

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