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Year: 2014 Volume: 9 Issue: 1

The effective control of a bleeding injury using a medical adhesive containing batroxobin.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	You, Kyung Eun Koo, Min-Ah Lee, Dae-Hyung Kwon, Byeong-Ju Lee, Mi Hee Hyon, Suong-Hyu Seomun, Young Kim, Jong-Tak Park, Jong-Chul
Description	Author Affiliation: You KE ( Cellbiocontrol Laboratory, Department of Medical Engineering, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, Korea. Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, Korea.)
Abstract	Many types of hemostatic agents have been studied for the effective control of bleeding. In this study, a powdery medical adhesive composed of aldehyded dextran and Îµ-poly (L-lysine) was used with the recombinant batroxobin. Batroxobin is a venomous component from the snake Bothrops atrox moojeni and catalyzes fibrinogen conversion to form soluble fibrin clots. This research aims to examine the performance of the batroxobin-containing adhesive for hemostasis, and evaluate its potential as a novel hemostatic adhesive. The fibrinogen conversion ability of batroxobin was evaluated by a fibrinogen clotting assay and a whole blood clotting assay. Both experiments demonstrated the effectiveness of the batroxobin-containing adhesive for blood clot formation. Animal experiments were also conducted. After a pricking wound was made in an ICR (imprinting control region) mouse liver, the adhesive and various concentrations of batroxobin were applied. The total amount of blood loss was reduced with increasing concentrations of batroxobin. For excessive bleeding conditions, the femoral artery wound model of SD (Sprague-Dawley) rats was adopted. With higher concentrations of batroxobin, hemostasis was more rapidly achieved. Histological analysis of the liver model also supports the hemostatic effects through fibrin clot formation. In conclusion, batroxobin and medical adhesive effectively facilitate blood coagulation, and could be developed for clinical use.
File Format	HTM / HTML
ISSN	17486041
e-ISSN	1748605X
Journal	Biomedical Materials
Issue Number	2
Volume Number	9
Language	English
Publisher	IOP Publishing
Publisher Date	2014-04-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Biomedical Engineering Bandages Batroxobin Administration & Dosage Blood Coagulation Drug Effects Hemorrhage Drug Therapy Hemostatics Adhesives Aldehydes Animals Bothrops Dextrans Chemistry Femoral Artery Pathology Fibrin Fibrinogen Hemostasis Liver Metabolism Mice Mice, Inbred Icr Polylysine Rats, Sprague-dawley Recombinant Proteins Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Chemistry Business and International Management Mechanics of Materials Biomaterials Bioengineering Biomedical Engineering

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Slounase, a Batroxobin Containing Activated Factor X Effectively Enhances Hemostatic Clot Formation and Reducing Bleeding in Hypocoagulant Conditions in Mice

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Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery.

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Recombinant factor VIIa reduces bleeding after blunt liver injury in coagulopathic, hypofibrinogenaemic pigs.

Fast in situ generated É -polylysine-poly (ethylene glycol) hydrogels as tissue adhesives and hemostatic materials using an enzyme-catalyzed method.

The effective control of a bleeding injury using a medical adhesive containing batroxobin.

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Slounase, a Batroxobin Containing Activated Factor X Effectively Enhances Hemostatic Clot Formation and Reducing Bleeding in Hypocoagulant Conditions in Mice

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The effective control of a bleeding injury using a medical adhesive containing batroxobin.