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Epidermal growth factor genetic variation associated with advanced cervical cancer in younger women.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Araújo, Ana Paula Catarino, Raquel Ribeiro, Ricardo Pereira, Deolinda Pinto, Daniela Medeiros, Rui
Description	Country affiliation: Portugal Author Affiliation: Araújo AP ( Molecular Oncology Group, Department of Medical Oncology, Portuguese Institute of Oncology-Porto, Portugal.)
Abstract	OBJECTIVES: Epidermal growth factor (EGF) stimulates cell proliferation by binding to its receptor (epidermal growth factor receptor), and the overexpression of this receptor is associated with poorer prognosis. The EGF gene presents a polymorphism at position 61 (A/G), associated with higher EGF production. We examined the association between this polymorphism and cervical cancer through a case-control study. METHODS: This study used the PCR-restriction fragment length polymorphism method on a sample of 384 women with cervical lesions and 500 controls of white ethnicity. RESULTS: In cases of cervical cancer, we found an increased risk of progression to advanced disease (The International Federation of Gynecology and Obstetrics stage IIb/IV) (odds ratios=2.05; 95% confidence intervals=1.11 to 3.79; P=0.021), and this risk was particularly evident in G carriers for younger women (odds ratios=2.96; 95% confidence intervals=1.41-6.20, P=0.003). CONCLUSIONS: We hypothesize the onset of an advanced disease-driven selective pressure due to the effect of oncogenic human papillomavirus types in a favorable genetic background observed in G carrier women. These results suggest that EGF functional polymorphism may influence cervical cancer prognosis through an EGF/epidermal growth factor receptor pathway.
File Format	HTM / HTML
ISSN	02773732
Issue Number	3
Volume Number	35
e-ISSN	1537453X
Journal	American Journal of Clinical Oncology
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2012-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Oncology Adenocarcinoma Genetics Carcinoma, Squamous Cell Cervical Intraepithelial Neoplasia Epidermal Growth Factor Polymorphism, Single Nucleotide Uterine Cervical Neoplasms Pathology Adult Case-control Studies Dna Female Follow-up Studies Genetic Predisposition To Disease Humans Middle Aged Neoplasm Invasiveness Neoplasm Staging Polymerase Chain Reaction Prognosis Receptor, Epidermal Growth Factor Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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