NDLI: Metformin-Induced Fixed-Drug Eruption Confirmed by Multiple Exposures.

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Metformin-Induced Fixed-Drug Eruption Confirmed by Multiple Exposures.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Steber, Carolyn J. Perkins, Scott L. Harris, Kira B.
Description	Country affiliation: United States Author Affiliation: Steber CJ ( Levine College of Health Sciences, Wingate University, Wingate, NC, USA.); Perkins SL ( College of Pharmacy and Health Sciences, Campbell University, Buies Creek, NC, USA.); Harris KB ( Levine College of Health Sciences, Wingate University, Wingate, NC, USA.)
Abstract	BACKGROUND: A fixed-drug eruption (FDE) is a reaction characterized by cutaneous lesions that appear due to exposure to a particular drug. Barbiturates, carbamazepine, sulfamethoxazole, and tetracyclines have all been associated with causation of FDEs. Although these drugs are more commonly associated with FDEs, any introduction of a medication has the potential to result in a FDE. Metformin, a commonly used medication to improve glycemic control, has been reported to cause dermatologic reactions in some case reports, but only a single previously documented case report discusses the potential of metformin-associated FDE. CASE REPORT: We describe a 56-year-old woman who developed a FDE with multiple exposures to metformin. Upon each exposure, small, round, erythematic lesions developed on the palms of the hands and soles of the feet; these lesions resolved each time after discontinuation of metformin. According to the Naranjo scale, there is a definite association between metformin and FDE in this case (score of 8). CONCLUSIONS: This report contributes to the limited documented literature on metformin-induced FDE. Clinicians should be made aware of possible FDEs associated with this commonly used medication.
File Format	HTM / HTML
e-ISSN	19415923
Journal	American Journal of Case Reports
Volume Number	17
Language	English
Publisher	International Scientific Information
Publisher Date	2016-04-08
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Medicine Drug Eruptions Etiology Hypoglycemic Agents Adverse Effects Metformin Diabetes Mellitus, Type 2 Drug Therapy
Content Type	Text
Resource Type	Case study Article

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