NDLI: Habit formation: implications for alcoholism research.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	O'Tousa, David Grahame, Nicholas
Description	Country affiliation: United States Author Affiliation: O'Tousa D ( Department of Psychology, Indiana University - Purdue University Indianapolis, Indianapolis, IN, USA.); Grahame N ( Department of Psychology, Indiana University - Purdue University Indianapolis, Indianapolis, IN, USA. Electronic address: ngrahame@iupui.edu.)
Abstract	Characteristics of individuals with severe alcohol use disorders include heightened cue sensitivity, compulsive seeking, craving, and continued alcohol use in the face of negative consequences. Animal models are useful for understanding behavioral and neurological mechanisms underlying problematic alcohol use. Seeking of operant reinforcers including alcohol is processed by two mechanisms, commonly referred to as 'goal-directed' (action-outcome) and 'habitual' (stimulus-response). As substance use disorders are characterized by continued use regardless of unfavorable outcomes, it is plausible that drug use causes an unnatural disruption of these mechanisms. We present a critical analysis of literature pertaining to behavioral neuroscience alcoholism research involving habit formation. Traditionally, when operant behavior is unaffected by a loss of subjective value of a reinforcer (devaluation), the behavior is considered habitual. Acquisition of instrumental behavior requires corticostriatal mechanisms that depend heavily on the prefrontal cortex and ventral striatum, whereas practiced behavior is more predominantly controlled by the dorsal striatum. Dopaminergic signaling is necessary for the neurological adaptations involved in stimulus-response action, and drugs of abuse appear to facilitate habitual behavior through high levels of dopamine release. Evidence suggests that the use of alcohol as a reinforcer expedites habit formation, and that a history of alcohol use produces alterations in striatal morphology, aids habit learning for non-psychoactive reinforcers, and promotes alcohol drinking despite aversive adulterants. In this review, we suggest directions for future alcoholism research that seeks to measure action made despite a devalued outcome, including procedural modifications and genotypic, pharmacological, or neurological manipulations. Most alcoholism models currently in use fail to reach substantial blood ethanol concentrations, a shortcoming that may be alleviated through the use of high-drinking rodent lines. Additionally, satiety, one common mechanism of devaluing reinforcers, is not recommended for alcohol research because the psychoactive effects of alcohol depress response rates, mimicking devaluation effects. Overall, further research of habit formation and potentially related perseverative behaviors could be invaluable in discovering genetic variance, traits that correlate with persistent alcohol seeking, implicated neural structures and processes of alcohol use, and eventually novel pharmacological treatment for alcoholism.
File Format	HTM / HTML
ISSN	07418329
e-ISSN	18736823
DOI	10.1016/j.alcohol.2014.02.004
Journal	Alcohol
Issue Number	4
Volume Number	48
Language	English
Publisher	Elsevier
Publisher Date	2014-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Substance-Related Disorders Alcoholism Conditioning, Operant Habits Alcohol-related Disorders Physiopathology Animals Behavior, Addictive Physiology Corpus Striatum Dopamine Secretion Ethanol Pharmacology Models, Animal Research Design Sex Factors Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Neurology Medicine Behavioral Neuroscience Health (social science) Biochemistry Toxicology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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