NDLI: Chronic ethanol intake leads to structural and molecular alterations in the rat endometrium.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Martinez, Marcelo Milton, Flora A. Pinheiro, Patricia Fernanda F. Almeida-Francia, Camila C. D. Cagnon-Quitete, Valeria H. A. Tirapelli, Luiz F. Padovani, Carlos Roberto Chuffa, Luiz Gustavo A. Martinez, Francisco Eduardo
Description	Country affiliation: Brazil Author Affiliation: Martinez M ( Department of Morphology and Pathology, UFSCar, São Carlos, SP, Brazil.); Milton FA ( Department of Morphology and Pathology, UFSCar, São Carlos, SP, Brazil.); Pinheiro PF ( Department of Anatomy, UNESP, Botucatu, SP, Brazil.); Almeida-Francia CC ( Department of Anatomy, UNESP, Botucatu, SP, Brazil.); Cagnon-Quitete VH ( Department of Anatomy, Cellular Biology, Physiology and Biophysics, UNICAMP, Campinas, SP, Brazil.); Tirapelli LF ( Department of Surgery and Anatomy, USP, Ribeirão Preto, SP, Brazil.); Padovani CR ( Department of Biostatistics, UNESP, Botucatu, SP, Brazil.); Chuffa LG ( Department of Anatomy, UNESP, Botucatu, SP, Brazil.); Martinez FE ( Department of Anatomy, UNESP, Botucatu, SP, Brazil. Electronic address: martinez@ibb.unesp.br.)
Abstract	We described the effects of low- and high-dose ethanol intake on the structure and apoptosis signaling of the uterine endometrium of UChA and UChB rats (animals with voluntary ethanol consumption). Thirty adult female rats, 90 days old, were divided into three groups (n = 10/group): UChA rats fed with 10% (v/v) ethanol ad libitum (free choice for water or ethanol) drinking < 1.9 g/kg/day; UChB rats fed with 10% (v/v) ethanol ad libitum (free choice for water or ethanol) drinking from 2 to 5 g/kg/day; control rats without ethanol (only water). After 120 days of treatment, rats displaying estrus were euthanized. Uterine epithelial cells of the UCh rats showed dilated cisterns of the rough endoplasmic reticulum, presence of lipid droplets, altered nuclear chromatin, and disrupted mitochondria. The UCh rats exhibited intense atrophied epithelial cells with smaller areas and perimeters of cytoplasm and nuclei. The endometrium of UChA rats showed higher levels of caspase-3 while Xiap and Bcl2 varied from moderate to weak. Both UChA and UChB rats exhibited a stronger immunoreaction to Ki-67 and IGFR-1 on epithelial and stromal cells. Chronic ethanol intake leads to structural and molecular alterations in the uterine endometrium of UCh rats, regardless of low- or high-dose consumption, promoting reproductive disorders.
File Format	HTM / HTML
ISSN	07418329
Journal	Alcohol
Volume Number	52
e-ISSN	18736823
Language	English
Publisher	Elsevier
Publisher Date	2016-05-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Substance-Related Disorders
Content Type	Text
Resource Type	Article
Subject	Neurology Medicine Behavioral Neuroscience Health (social science) Biochemistry Toxicology

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