NDLI: Common genes regulate food and ethanol intake in Drosophila.

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Common genes regulate food and ethanol intake in Drosophila.

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Common genes regulate food and ethanol intake in Drosophila.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sekhon, Morgan L. Lamina, Omoteniola Hogan, Kerry E. Kliethermes, Christopher L.
Description	Country affiliation: United States Author Affiliation: Sekhon ML ( Drake University, Department of Psychology and Neuroscience, Des Moines, IA, USA.); Lamina O ( Drake University, Department of Psychology and Neuroscience, Des Moines, IA, USA.); Hogan KE ( Drake University, Department of Psychology and Neuroscience, Des Moines, IA, USA.); Kliethermes CL ( Drake University, Department of Psychology and Neuroscience, Des Moines, IA, USA. Electronic address: c.kliethermes@drake.edu.)
Abstract	The abuse liability of alcohol (ethanol) is believed to result in part from its actions on neurobiological substrates that underlie the motivation toward food and other natural reinforcers, and a growing body of evidence indicates that these substrates are broadly conserved among animal phyla. Understanding the extent to which the substrates regulating ethanol and food intake overlap is an important step toward developing therapeutics that selectively reduce ethanol intake. In the current experiments, we measured food and ethanol intake in Recombinant Inbred (RI) lines of Drosophila melanogaster using several assays, and then calculated genetic correlations to estimate the degree to which common genes might underlie behavior in these assays. We found that food intake and ethanol intake as measured in the capillary assay are genetically correlated traits in D. melanogaster, as well as in a panel of 11 Drosophila species that we tested subsequently. RI line differences in food intake in a dyed food assay were genetically unrelated to ethanol intake in the capillary assay or to ethanol preference measured using an olfactory trap apparatus. Using publicly available gene expression data, we found that expression profiles across the RI lines of a number of genes (including the D2-like dopamine receptor, DOPA decarboxylase, and fruitless) correlated with the RI line differences in food and ethanol intake we measured, while the expression profiles of other genes, including NPF, and the NPF and 5-HT2 receptors, correlated only with ethanol intake or preference. Our results suggest that food and ethanol intake are regulated by some common genes in Drosophila, but that other genes regulate ethanol intake independently of food intake. These results have implications toward the development of therapeutics that preferentially reduce ethanol intake.
File Format	HTM / HTML
ISSN	07418329
Journal	Alcohol
Volume Number	53
e-ISSN	18736823
Language	English
Publisher	Elsevier
Publisher Date	2016-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Substance-Related Disorders
Content Type	Text
Resource Type	Article
Subject	Neurology Medicine Behavioral Neuroscience Health (social science) Biochemistry Toxicology

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