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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Fein, George Camchong, Jazmin Cardenas, Valerie A. Stenger, Andy |
| Description | Author Affiliation: Fein G ( Neurobehavioral Research, Inc., 840 Alua Street, Suite 203, Wailuku, HI 96793, USA); Camchong J ( Department of Psychiatry, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN 55414, USA.); Cardenas VA ( Neurobehavioral Research, Inc., 840 Alua Street, Suite 203, Wailuku, HI 96793, USA.); Stenger A ( Department of Medicine, John A. Burns School of Medicine, University of Hawaii, MR Research, 1356 Lusitania St., 7th Floor UHT, Honolulu, HI 96813, USA. Electronic address: stenger@hawaii.edu.) |
| Abstract | Alcoholism is characterized by a lack of control over an impulsive and compulsive drive toward excessive alcohol consumption despite significant negative consequences; our previous work demonstrated that successful abstinence is characterized by decreased resting-state synchrony (RSS) as measured with functional magnetic resonance imaging (fMRI), within appetitive drive networks and increased RSS in emotion regulation and inhibitory executive control networks. Our hypothesis is that LTAA (Long-Term Abstinent Alcoholics) with a current major depressive disorder (MDD) drank primarily to deal with the negative affect associated with their MDD and not because of a heightened externalizing diathesis (including heightened appetitive drive), and consequently, in achieving and maintaining abstinence, such individuals would not exhibit the RSS adaptations characteristic of pure alcoholics. We studied 69 NSAC (Non Substance Abusing Controls) and 40 LTAA (8 with current MDD, 32 without a current MDD) using resting-state fMRI and seed based connectivity analyses. In the inhibitory executive control network (nucleus accumbens vs. left dorsolateral prefrontal cortex), LTAA with a current MDD showed increased synchrony compared to NSAC. In the emotion regulation executive control network (subgenual anterior cingulate cortex vs. right dorsolateral prefrontal cortex), LTAA with current MDD did not show increased RSS. In the appetitive drive networks (nucleus accumbens vs, aspects of the caudate nucleus and thalamus), LTAA with a current MDD did not show a reduction of RSS compared to NSAC, but LTAA without a current MDD did. These results suggest different pathways to their alcohol dependence in LTAA with vs. without a current MDD, and different patterns of brain activity in long-term abstinence, suggesting different treatment needs. |
| File Format | HTM / HTML |
| ISSN | 07418329 |
| Journal | Alcohol |
| Volume Number | 59 |
| e-ISSN | 18736823 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-03-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Substance-Related Disorders |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Medicine Behavioral Neuroscience Health (social science) Biochemistry Toxicology |
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