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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Leonardi, Rosalia Loreto, Carla Talic, Nabeel Caltabiano, Rosario Musumeci, Giuseppe |
| Description | Country affiliation: Italy Author Affiliation: Leonardi R ( Department of Dentistry, Faculty of Dentistry, University of Catania, Policlinico Universitario, Catania, Italy. rleonard@unict.it) |
| Abstract | Lubricin is a protein which contributes to the boundary lubrication, facilitating low friction levels at the interfacing surfaces of joints. In tendons and ligaments it facilitates the relative movement of collagen bundles. Its expression is affected by mechanical signals and cytokines. During application of orthodontic forces to teeth, there is a transduction of mechanical forces to the cells of the periodontal ligament (PDL), which triggers several biological reactions causing the synthesis of prostaglandins, cytokines and growth factors. The aim of the present study was to examine the immunolocalization of lubricin and to evaluate if it is time-dependently and differentially detected within the PDL following the application of orthodontic forces to create areas of compression and tension. This was achieved by placing elastic bands between the maxillary first and second molars of 16 male Sprague-Dawley rats (each weighing 120-200g) for 12 and 24h. The molar-bearing segments were dissected and processed for histological and immunohistochemical examination. Binding of a monoclonal antibody was used to evaluate lubricin localization using an indirect streptavidin/biotin immunperoxidase technique. Lubricin, was constitutively expressed in the PDL of rat molars. After the experimental force was applied to the tooth, lubricin was down-regulated, on both sides (compression and tension) of the PDL, in a time-dependent fashion, although to a different extent, being at any time more expressed on the tension side. Furthermore, in every sample, almost all PDL cells in the adjacent tooth cementum and alveolar bone, were more heavily immunolabeled by lubricin antibody, contrary to those located in the central portion of the PDL. Lubricin expression therefore seems related to PDL remodeling and tooth displacement following the application of an orthodontic force, and it appears that lubricin may play an important role during tooth movement. |
| File Format | HTM / HTML |
| ISSN | 00651281 |
| Issue Number | 7 |
| Volume Number | 114 |
| e-ISSN | 16180372 |
| Journal | Acta Histochemica |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-11-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Histocytochemistry Glycoproteins Metabolism Periodontal Ligament Tooth Movement Animals Down-regulation Extracellular Matrix Male Molar Physiology Cytology Rats Rats, Sprague-dawley Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Histology |
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