NDLI: Multiple myeloma with monoclonal free IgG3 heavy chains and free kappa light chains.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Richter, Alex G. Harding, Stephen Huissoon, Aarnoud Drayson, Mark Pratt, Guy
Description	Country affiliation: United kingdom Author Affiliation: Richter AG ( Department of Immunology, Birmingham Heartlands Hospital, Birmingham, UK. alex.richter@heartofengland.nhs.uk)
Abstract	We describe the case of a 34-year-old gentleman investigated for persistent neutropaenia following two episodes of pneumonia. Specialist investigations led to the diagnosis of multiple myeloma (MM) producing a truncated monoclonal gamma(3) heavy chain (HC) immunoglobulin molecule unattached to a light chain (LC) with atypical features for both MM and HC disease. Western blot showed gamma(3)HC was truncated with a large deletion (75 kDa). Flow cytometry of the bone marrow aspirate revealed an unusual staining pattern. This plasma cell dyscrasia was also unusual in that a subpopulation (30%) secreted large quantities of free LC (FLC) as well as truncated IgG HC. This is the first description, investigation and treatment of MM with a plasma cell population producing truncated gamma(3)HC and kappaFLC M-proteins and illustrates a number of unique immunological and clinical features.
File Format	HTM / HTML
ISSN	00015792
Issue Number	3
Volume Number	123
e-ISSN	14219662
Journal	Acta Haematologica
Language	English
Publisher	Karger
Publisher Date	2010-01-01
Publisher Place	Switzerland
Access Restriction	Subscribed
Subject Keyword	Discipline Hematology Immunoglobulin Gamma-chains Blood Immunoglobulin Kappa-chains Multiple Myeloma Immunology Adult Humans Chemistry Male Therapy Peripheral Blood Stem Cell Transplantation Treatment Outcome Case Reports Journal Article
Content Type	Text
Resource Type	Case study Article
Subject	Hematology

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