NDLI: Active stiffening of mitral valve leaflets in the beating heart.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Itoh, Akinobu Krishnamurthy, Gaurav Swanson, Julia C. Ennis, Daniel B. Bothe, Wolfgang Kuhl, Ellen Karlsson, Matts Davis, Lauren R. Miller, D. Craig Ingels, Neil B.
Description	Country affiliation: United States Author Affiliation: Itoh A ( Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, California, USA.)
Abstract	The anterior leaflet of the mitral valve (MV), viewed traditionally as a passive membrane, is shown to be a highly active structure in the beating heart. Two types of leaflet contractile activity are demonstrated: 1) a brief twitch at the beginning of each beat (reflecting contraction of myocytes in the leaflet in communication with and excited by left atrial muscle) that is relaxed by midsystole and whose contractile activity is eliminated with beta-receptor blockade and 2) sustained tone during isovolumic relaxation, insensitive to beta-blockade, but doubled by stimulation of the neurally rich region of aortic-mitral continuity. These findings raise the possibility that these leaflets are neurally controlled tissues, with potentially adaptive capabilities to meet the changing physiological demands on the heart. They also provide a basis for a permanent paradigm shift from one viewing the leaflets as passive flaps to one viewing them as active tissues whose complex function and dysfunction must be taken into account when considering not only therapeutic approaches to MV disease, but even the definitions of MV disease itself.
File Format	HTM / HTML
ISSN	03636135
e-ISSN	15221539
DOI	10.1152/ajpheart.00120.2009
Journal	AJP: Heart and Circulatory Physiology
Issue Number	6
Volume Number	296
Language	English
Publisher	American Physiological Society
Publisher Date	2009-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Discipline Cardiology Adaptation, Physiological Physiology Finite Element Analysis Mitral Valve Models, Cardiovascular Myocardial Contraction Adrenergic Beta-antagonists Pharmacology Animals Collagen Elasticity Electric Stimulation Muscle, Smooth Drug Effects Papillary Muscles Propanolamines Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Cardiology and Cardiovascular Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Active stiffening of mitral valve leaflets in the beating heart

Transient stiffening of mitral valve leaflets in the beating heart

Dissociation between cardiomyocyte function and remodeling with beta-adrenergic receptor blockade in isolated canine mitral regurgitation.

Differences in mitral valve-left ventricle dimensions between a beating heart and during saline injection test.

Mitral valve repair for post-myocardial infarction papillary muscle rupture.

Mitral regurgitation: has another magic bullet bitten the dust?

Papillary muscle dysfunction and ischemic mitral regurgitation.

Inotropic response to DPI 201-106 in the failing human heart.

Beta 1- and beta 2-adrenoceptor antagonist activities of ICI-215001, a putative beta 3-adrenoceptor agonist.

Active stiffening of mitral valve leaflets in the beating heart.

Similar Documents

Active stiffening of mitral valve leaflets in the beating heart

Transient stiffening of mitral valve leaflets in the beating heart

Dissociation between cardiomyocyte function and remodeling with beta-adrenergic receptor blockade in isolated canine mitral regurgitation.

Differences in mitral valve-left ventricle dimensions between a beating heart and during saline injection test.

Mitral valve repair for post-myocardial infarction papillary muscle rupture.

Mitral regurgitation: has another magic bullet bitten the dust?

Papillary muscle dysfunction and ischemic mitral regurgitation.

Inotropic response to DPI 201-106 in the failing human heart.

Beta 1- and beta 2-adrenoceptor antagonist activities of ICI-215001, a putative beta 3-adrenoceptor agonist.

Active stiffening of mitral valve leaflets in the beating heart.