NDLI: 3,4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, attenuates acetaminophen (APAP)-induced liver injury through activation of Nrf-2.

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3,4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, attenuates acetaminophen (APAP)-induced liver injury through activation of Nrf-2.

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3,4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, attenuates acetaminophen (APAP)-induced liver injury through activation of Nrf-2.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xue, Huiting Xie, Wenyan Jiang, Zhihui Wang, Meng Wang, Jian Zhao, Hongqiong Zhang, Xiaoying
Description	Author Affiliation: Xue H ( a College of Veterinary Medicine, Xinjiang Agricultural University , Urumqi , PR China and.); Xie W ( b College of Veterinary Medicine, Northwest A&F University , Yangling , PR China.); Jiang Z ( b College of Veterinary Medicine, Northwest A&F University , Yangling , PR China.); Wang M ( b College of Veterinary Medicine, Northwest A&F University , Yangling , PR China.); Wang J ( b College of Veterinary Medicine, Northwest A&F University , Yangling , PR China.); Zhao H ( b College of Veterinary Medicine, Northwest A&F University , Yangling , PR China.); Zhang X ( a College of Veterinary Medicine, Xinjiang Agricultural University , Urumqi , PR China and.)
Abstract	1. Acetaminophen (APAP) overdose leads to severe hepatotoxicity. 3,4-dihydroxyphenylacetic acid (DOPAC) is a scarcely studied microbiota-derived metabolite of quercetin. The aim of this study was to determine the protective effect of DOPAC against APAP-induced liver injury. 2. Mice were treated intragastrically with DOPAC (10, 20 or 50 mg/kg) for 3 days before APAP (300 mg/kg) injection. APAP alone caused increase in serum aminotransferase levels and changes in hepatic histopathology. APAP also promoted oxidative stress by increasing lipid peroxidation and decreasing anti-oxidant enzyme activities. These events led to hepatocellular necrosis and reduced liver function. DOPAC increased nuclear factor erythroid 2-related factor 2 (Nrf-2) translocation to the nucleus and enhanced the expression of phase II enzymes and anti-oxidant enzymes, and thereby reduced APAP hepatotoxicity and enhanced anti-oxidant ability. 3. Our data provide evidence that DOPAC protected the liver against APAP-induced injury, which is involved in Nrf-2 activation, implying that DOPAC can be considered as a potential natural hepatoprotective agent.
File Format	HTM / HTML
ISSN	00498254
Issue Number	10
Journal	Xenobiotica
Volume Number	46
e-ISSN	13665928
Language	English
Publisher	Taylor & Francis
Publisher Date	2016-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Biochemistry Toxicology Pharmacology

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3,4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, attenuates acetaminophen (APAP)-induced liver injury through activation of Nrf-2.