NDLI: Acrolein health effects.

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Acrolein health effects.

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Acrolein health effects.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Faroon, O. Roney, N. Taylor, J. Ashizawa, A. Lumpkin, M. H. Plewak, D. J.
Description	Country affiliation: United States Author Affiliation: Faroon O ( ATSDR, Division of Toxicology and Environmental Medicine, Atlanta, Georgia, USA. oxs0@CDC.GOV)
Abstract	Acrolein is a chemical used as an intermediate reactive aldehyde in chemical industry. It is used for synthesis of many organic substances, methionine production, and methyl chloride refrigerant. The general population is exposed to acrolein via smoking, second-hand smoke, exposure to wood and plastic smoke. Firefighters and population living or working in areas with heavy automotive traffic may expose to higher level of acrolein via inhalation of smoke or automotive exhaust. Degradation of acrolein in all environmental media occurs rapidly, therefore, environmental accumulation is not expected. Acrolein degrade in 6A days when applied to surface water, and it has not been found as a contaminant in municipal drinking water. Acrolein vapor may cause eye, nasal and respiratory tract irritations in low level exposure. A decrease in breathing rate was reported by volunteers acutely exposed to 0.3A ppm of acrolein. At similar level, mild nasal epithelial dysplasia, necrosis, and focal basal cell metaplasia have been observed in rats. The acrolein effects on gastrointestinal mucosa in the animals include epithelial hyperplasia, ulceration, and hemorrhage. The severity of the effects is dose dependent. Acrolein induces the respiratory, ocular, and gastrointestinal irritations by inducing the release of peptides in nerve terminals innervating these systems. Levels of acrolein between 22 and 249 ppm for 10 min induced a dose-related decrease in substance P (a short-chain polypeptide that functions as a neurotransmitter or neuromodulator).
File Format	HTM / HTML
ISSN	07482337
Issue Number	7
Volume Number	24
e-ISSN	14770393
Journal	Toxicology and Industrial Health
Language	English
Publisher	Sage Publications
Publisher Date	2008-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Occupational Medicine Discipline Toxicology Acrolein Toxicity Environmental Pollutants Pharmacokinetics Animals Dose-response Relationship, Drug Humans Risk Assessment Toxicity Tests Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology

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