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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Heeba, Gehan H. Mahmoud, Magda E. El Hanafy, Amr A. |
| Description | Country affiliation: Egypt Author Affiliation: Heeba GH ( Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, El-Minia, Egypt ghhh70@yahoo.com.); Mahmoud ME ( Department of Agricultural Chemistry, Faculty of Agriculture, Minia University, El-Minia, Egypt.); El Hanafy AA ( Department of Biology, Faculty of Sciences, King Abdulaziz University, Gedda, Saudi Arabia Department of Nucleic Acid Research, Genetic Engineering and Biotechnology Research Institute, City for Scientific Researches and Technology Application, Borg EL-Arab, Alexandria, Egypt.) |
| Abstract | Flavonoids are group of compounds that have been shown to possess potent anti-inflammatory effects in both cellular and animal models of inflammation. In the current study, the single and combined effects of the two flavonoids, curcumin and quercetin, against carrageenan-induced acute inflammation in rats were evaluated with emphasis on the role of oxidative stress, anti-inflammatory enzyme, heme oxygenase-1 (HO-1) and proinflammatory cytokine, tumor necrosis factor-alpha (TNF- ). Curcumin (50 mg/kg), quercetin (50 mg/kg) and a combination of both were orally administered for 14 days before carrageenan injection in rats and compared with the reference nonsteroidal anti-inflammatory drug, indomethacin (10 mg/kg). The percentage increase in paw thickness was calculated. Frozen hind paws were used for the estimation of lipid peroxides (malondialdehyde, MDA), nitric oxide (NO), reduced glutathione (GSH), TNF- level and HO-1 messenger RNA (mRNA) expression. Formalin-fixed hind paws were used for histopathological examination. Results showed that both curcumin and quercetin caused reduction in carrageenin-induced edema and lymphocytes infiltration along with the decrease is being even higher in case of their combination. Additionally, both flavonoids reduced MDA and NO formation, and restored GSH contents in the paw. Furthermore, both flavonoids increased HO-1 mRNA expression and decreased the elevated TNF- level. Results showed that both flavonoids moderately lowered inflammation, while their combination was more effective. Accordingly, this study suggests that the reduction in oxidative stress and modulation of HO-1 mRNA expression and TNF- release by curcumin and quercetin may contribute to the synergistic anti-inflammatory effects of these two flavonoids upon combination. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 6 |
| Volume Number | 30 |
| e-ISSN | 14770393 |
| Journal | Toxicology and Industrial Health |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2014-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology Anti-inflammatory Agents Pharmacology Curcumin Heme Oxygenase (decyclizing) Physiology Quercetin Tumor Necrosis Factor-alpha Animals Anti-inflammatory Agents, Non-steroidal Administration & Dosage Drug Interactions Indomethacin Inflammation Drug Therapy Male Oxidative Stress Drug Effects Rats Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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