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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Polat, Zühal Aydin, Elanur Türkez, Hasan Aslan, Ali |
| Description | Country affiliation: Turkey Author Affiliation: Polat Z ( Department of Biology, Faculty of Science, Atatürk University, Erzurum, Turkey zuhal.polat2013@gmail.com.); Aydin E ( Department of Biology, Faculty of Science, Atatürk University, Erzurum, Turkey.); Türkez H ( Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, Turkey.); Aslan A ( Department of Biology, Kazim Karabekir Education Faculty, Atatürk University, Erzurum, Turkey.) |
| Abstract | Lichens are symbiotic organisms composed of fungi and algae and are very common in Turkey. Lichen secondary metabolites are mainly phenolic compounds produced by fungal partner of lichen symbiosis. Usnic acid (UA) is one of the most common lichen metabolites, and it was reported that to be effective for a wide range of pharmacological purposes including antiviral, antitumor, and antiprotozoal. However, there are limited data on the genotoxic and antioxidant effects of UA in cultured human peripheral blood cells. Therefore, the aim of this thesis study was to investigate the genetic and oxidative effects of UA in cultured human blood cells (n = 5). The UA was added into culture tubes at various concentrations (0-200 µg/ml). Chromosomal aberrations (CA) and micronuclei (MN) tests were performed for genotoxic damage influences estimation. In addition, biochemical parameters (total antioxidant capacity (TAC) and total oxidative status (TOS)) were examined to determine oxidative effects. In our in vitro test systems, it was observed that UA had no mutagenic effects on human lymphocytes. Furthermore, our results indicated that low concentrations (1 and 5 µg/ml) of UA caused increases of TAC levels in cultured human blood cells. And, the TOS levels were not changed (p > 0.05) when all the concentrations (except for 200 µg/ml) of UA were applied. In conclusion, UA can be a new resource of therapeutics as recognized in this study with their nonmutagenic and antioxidant features. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 3 |
| Journal | Toxicology and Industrial Health |
| Volume Number | 32 |
| e-ISSN | 14770393 |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2016-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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