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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sapmaz, Hilal Irmak Sarsilmaz, Mustafa Gödekmerdan, Ahmet Ögetürk, Murat Tas, Ufuk Köse, Evren |
| Description | Country affiliation: Turkey Author Affiliation: Sapmaz HI ( Department of Anatomy, Faculty of Medicine, Inonu University, Malatya, Turkey.); Sarsilmaz M ( Department of Anatomy, Faculty of Medicine, Sifa University, Izmir, Turkey msarsilmaz@hotmail.com.); Gödekmerdan A ( Department of Microbiology, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.); Ögetürk M ( Department of Anatomy, Faculty of Medicine, Firat University, Elazig, Turkey.); Tas U ( Department of Anatomy, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey.); Köse E ( Department of Anatomy, Faculty of Medicine, Inonu University, Malatya, Turkey.) |
| Abstract | AIM: This study was carried out to determine the effects of formaldehyde (FA) inhalation on the humoral immunity of rats and the protective effect of Nigella sativa (NS) oil. MATERIALS AND METHODS: The rats (n = 33) were divided into five groups, with five animals in the control group (FA-free air) and seven in the other four groups. Group FA1 was exposed to FA (5 ppm), group FA + NS1 was treated with NS and exposed to FA (5 ppm), group FA2 was exposed to FA (10 ppm), and group FA + NS2 was treated with NS and exposed to FA (10 ppm). At the end of a 4-week study period, blood samples were collected. Enzyme-linked immunosorbent assay was used to determine the levels of serum total immunoglobulin A (IgA), total immunoglobulin M (IgM), total immunoglobulin G (IgG), and complement 3 (C3). RESULTS: FA inhalation significantly increased serum IgA, IgM, and C3 levels and decreased serum IgG levels compared with the control group. NS administration decreased serum IgA, IgM, and C3 levels, which were induced by FA inhalation. CONCLUSION: FA inhalation significantly increased acute antibody responses and C3 levels in a dose-dependent manner compared with the control group. FA inhalation decreased the secondary immune response compared with the control group. Levels of acute antibody responses and complement following exposure to FA inhalation returned to normal following treatment with NS (immunoregulatory effect). However, NS did not affect the secondary immune response. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 9 |
| Journal | Toxicology and Industrial Health |
| Volume Number | 32 |
| e-ISSN | 14770393 |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2016-09-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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