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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shimoyama, Natsumi Nakatsuji, Shunji Andoh, Rie Yamaguchi, Yuko Tamura, Kazutoshi Hoshiya, Toru |
| Description | Country affiliation: Japan Author Affiliation: Shimoyama N ( Pathology Division, Gotemba Laboratories, BoZo Research Center Inc., Shizuoka, Japan shimoyama-natsumi@bozo.co.jp.); Nakatsuji S ( Toxicologic Pathology, Drug Safety Research Laboratories, Astellas Pharma Inc., Osaka, Japan.); Andoh R ( Pathology Division, Gotemba Laboratories, BoZo Research Center Inc., Shizuoka, Japan.); Yamaguchi Y ( Pathology Division, Gotemba Laboratories, BoZo Research Center Inc., Shizuoka, Japan.); Tamura K ( Pathology Division, Gotemba Laboratories, BoZo Research Center Inc., Shizuoka, Japan.); Hoshiya T ( Pathology Division, Gotemba Laboratories, BoZo Research Center Inc., Shizuoka, Japan.) |
| Abstract | Intranuclear and cytoplasmic inclusions in the renal proximal tubular epithelium were observed in nontreated male and female Wistar Hannover rats in a 26-week study (32 weeks of age) and a 104-week study (110 weeks of age). The incidence rates were less than 5% in these two studies. In affected animals, the inclusions were observed in more than 60% of proximal tubular epithelium as various sized (approximately 1-8 µm in diameter) round and eosinophilic materials, but not in distal tubules, Henle's loop, or collecting ducts. Ultrastructurally, inclusions appeared finely granular, homogenous with middle-electron density, and without a limiting membrane. These inclusions were determined to be protein histochemically stained by Azan-Mallory and immunoreactive with an antibody against D-amino acid oxidase (DAO). There was no abnormality in in-life observations or in clinical test values suggestive of renal dysfunction. There were no associated degenerative or inflammatory changes in the kidneys, and no similar inclusions were observed in the other organs. These inclusions are very similar to propiverine hydrochloride (propiverine) and norepinephreine/serotonin reuptake inhibitor-induced inclusions. This is the first report of accumulation of DAO and formation of inclusions occurring spontaneously in rat kidneys. The data are important for toxicological studies using Wistar Hannover rats. |
| File Format | HTM / HTML |
| ISSN | 01926233 |
| Issue Number | 5 |
| Volume Number | 43 |
| e-ISSN | 15331601 |
| Journal | Toxicologic Pathology |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2015-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Discipline Pathology D-amino-acid Oxidase Metabolism Inclusion Bodies Enzymology Kidney Diseases Kidney Tubules, Proximal Animals Epithelium Pathology Female Intranuclear Inclusion Bodies Cytology Male Rats Rats, Wistar Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Toxicology Pathology and Forensic Medicine |
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