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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wenzel, Friedel Röthlisberger, Benno |
| Description | Author Affiliation: Wenzel F ( Abteilung Medizinische Genetik, Universitäts-Kinderspital beider Basel, Basel.) |
| Abstract | Most tumors are caused by acquired somatic mutations. For half a century now chromosomal anomalies in hematological neoplasia and to a much less extent in solid tumors are investigated by conventional cytogenetics. During all this time the significance of genetic factors for tumor classification increased continuously. Especially for haematological neoplasia, besides <> cytogenetic parameters, molecular genetic factors are becoming more and more important. For technical and analytical reasons conventional cytogenetics does not play a role in routine diagnostics of solid tumors. However, well known chromosome aberrations are increasingly investigated by fluorescence-in-situ Hybridization (FISH) and by molecular genetic methods. In the future microarray-based methods will become more and more important in the diagnostics of various tumors. |
| File Format | HTM / HTML |
| ISSN | 00405930 |
| Issue Number | 9 |
| Volume Number | 65 |
| e-ISSN | 16642864 |
| Journal | Therapeutische Umschau |
| Language | German |
| Publisher | Hogrefe Verlag |
| Publisher Date | 2008-09-01 |
| Publisher Place | Switzerland |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Therapeutics Chromosome Aberrations Cytogenetic Analysis Methods Dna Mutational Analysis Genetic Testing In Situ Hybridization, Fluorescence Neoplasms Diagnosis Genetics Genetic Predisposition To Disease Humans English Abstract Journal Article Review |
| Alternative Title | Impact of tumorcytogenetics in tumor diagnostics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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