NDLI: Antifungal Susceptibilities and Distribution of Candida Species Recovered from Blood Cultures over an 8-Year Period

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Antifungal Susceptibilities and Distribution of Candida Species Recovered from Blood Cultures over an 8-Year Period

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Antifungal Susceptibilities and Distribution of Candida Species Recovered from Blood Cultures over an 8-Year Period

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chae, M. J. Shin, J. H. Cho, D. Kee, S. J. Kim, S. H. Shin, M. G. Shin, D. H. Jung, S. I. Suh, S. P. Ryang, D. W.
Description	Responsible library: WPRO
Abstract	BACKGROUND: Nosocomial candidemia has increased over the past 2 decades. The rank order of occurrence and antifungal resistance profiles of the various species of Candida causing candidemia is important in establishing empiric treatment protocols. METHODS: We investigated antifungal susceptibilities and distribution of Candida species recovered from blood cultures over an 8-year period in Chonnam National University Hospital. The results obtained from the period 1994 through 1997 (period 1) were compared with those from the period 1998 through 2001 (period 2). Minimal inhibitory concentrations (MICs) of amphotericin B, fluconazole and itraconazole for each isolate were determined by the NCCLS broth microdilution method. RESULTS: During an 8-year period, 805 strains of Candida species were isolated from 290 patients. In period 1, the Candida species recovered most frequently from candidemic patients was C.albicans(29.5%), followed by C. parapsilosis (25.9%) and C. tropicalis (18.8%). In period 2, C. parapsilosis (31.5%) was the most common species, followed by C. albicans (23.6%), and C.glabrata (14.0%). These data, compared to those of period 1, indicate a variation in species distribution, with the proportions of C. glabrata increasing by 10.0% (P<0.005). MIC50 of amphotericin B, fluconazole and itraconazole for each species did not change appreciably during the two periods. However, resistance to fluconazole (>or=64 microgram/mL) and itraconazole (>or=1 microgram/mL) was observed more frequently in period 2 (8.0% and 20.9%, respectively) than in period 1 (2.0% and 7.0%, respectively)(P<0.05). CONCLUSIONS: These data showed that MICs of amphotericin B, fluconazole and itraconazole for each species did not change during the 8-year span, but azole resistant Candida species such as C. glabrata, increased in the latter four years (period 2).
File Format	HTM / HTML
ISSN	22343806
e-ISSN	22343814
Journal	The Korean Journal of Laboratory Medicine
Issue Number	5
Volume Number	23
Language	Korean
Publisher	Korean Society for Laboratory Medicine
Publisher Date	2003-01-01
Publisher Place	Korea (South)
Access Restriction	Open
Subject Keyword	Discipline Medical Laboratory Technology Carbon Ion Candida Itraconazole Fluconazole Amphotericin B
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Clinical Biochemistry

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