NDLI: Recent guidelines and recommendations for laboratory detection of lupus anticoagulants.

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Recent guidelines and recommendations for laboratory detection of lupus anticoagulants.

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Recent guidelines and recommendations for laboratory detection of lupus anticoagulants.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Moore, Gary W.
Description	Country affiliation: United kingdom Author Affiliation: Moore GW ( Department of Haemostasis and Thrombosis, GSTS Pathology, Guy's & St. Thomas' NHS Foundation Hospitals Trust, London, England.)
Abstract	The International Society on Haemostasis and Thrombosis (ISTH) and the British Committee for Standards in Haematology (BCSH) have recently updated their lupus anticoagulant (LA) detection guidelines. The Clinical and Laboratory Standards Institute (CLSI) subsequently will publish its first LA guideline. General agreement exists on issues such as sample preparation, the use of dilute Russell viper venom time (dRVVT) in diagnostic repertoires, the use of normalized ratios, calculations to demonstrate phospholipid dependence, calculations to demonstrate inhibition, and interpretive reporting. The ISTH recommendation to employ only dRVVT and activated partial thromboplastin time is not mirrored in the BCSH and CLSI documents. The potential for false negatives in mixing tests is acknowledged by all panels, yet they remain mandated by ISTH as there are occasions when they are crucial to diagnostic accuracy. BCSH indicates that a negative mixing test need not exclude the presence of a LA, and CLSI reprioritizes test order to screen-confirm-mix, the latter being considered unnecessary in specific circumstances. Opinions in the guidelines differ on setting cutoff levels (i.e., 97.5th vs. 99th percentile for normally distributed data). All guidelines cover testing of anticoagulated patients, more detail being given by BCSH and CLSI, who suggest that Taipan snake venom time is a useful adjunct test in patients receiving vitamin K antagonists. Although complete agreement is not apparent, the guidelines represent significant moves toward engendering common practices.
File Format	HTM / HTML
ISSN	00946176
Issue Number	2
Volume Number	40
e-ISSN	10989064
Journal	Seminars in Thrombosis and Hemostasis
Language	English
Publisher	Thieme
Publisher Date	2014-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Vascular Diseases Discipline Hematology Antiphospholipid Syndrome Diagnosis Clinical Laboratory Techniques Standards Guidelines As Topic Lupus Coagulation Inhibitor Blood Anticoagulants Therapeutic Use Drug Therapy Blood Coagulation Tests Methods Humans Reagent Kits, Diagnostic Reproducibility Of Results Sensitivity And Specificity Journal Article
Content Type	Text
Resource Type	Article
Subject	Hematology Cardiology and Cardiovascular Medicine

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