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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mok, C. C. Ho, L. Y. To, C. H. |
| Spatial Coverage | Hong Kong |
| Description | Author Affiliation: Mok CC ( Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, SAR China. ccmok2005@yahoo.com) |
| Abstract | OBJECTIVES: To study the annual incidence and standardized incidence ratio (SIR) of cerebrovascular accident (CVA) in patients with systemic lupus erythematosus (SLE). SUBJECTS AND METHODS: The annual incidence of CVA from 1999 to 2007 in a longitudinal cohort of SLE patients was calculated each year and compared with that of the regional population within the same study period. Age-specific SIRs and outcome of CVA in SLE patients were also studied. RESULTS: In 2007, there were 490 SLE patients in our cohort. The mean annual incidence of CVA between 1999 and 2007 was 6.45/1000 patients and no obvious trend over time was observed. Of the 20 CVAs in patients with SLE, 18 (90%) were ischaemic stroke whereas two (10%) were haemorrhagic stroke. The mean SIR of all types of CVA in SLE patients was 2.02 [95% confidence interval (CI) 1.30-3.81; p = 0.002]. The SIR of ischaemic stroke decreased with age and the stroke incidence was no longer significantly higher than that of the population in patients aged >or= 60 years. Haemorrhagic stroke occurred mainly in younger SLE patients. The duration of hospitalization and the mortality rate for CVA was non-significantly higher in SLE than in non-SLE patients. CONCLUSIONS: The incidence of CVA in SLE remained constant over the 8 years between 1999 and 2007. Younger SLE patients are at substantially increased risk of CVA compared to age-matched population. The duration of hospitalization and the mortality rate for CVA are similar in SLE and non-SLE patients. |
| File Format | HTM / HTML |
| ISSN | 03009742 |
| e-ISSN | 15027732 |
| Journal | Scandinavian Journal of Rheumatology |
| Issue Number | 5 |
| Volume Number | 38 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2009-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Rheumatology Lupus Erythematosus, Systemic Complications Epidemiology Stroke Chi-square Distribution Cohort Studies Confidence Intervals Longitudinal Studies Odds Ratio Registries |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology Rheumatology |
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