NDLI: KRAS et adénocarcinome bronchique. Entre déceptions et espoirs.

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KRAS et adénocarcinome bronchique. Entre déceptions et espoirs.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Guibert, N. Ilie, M. Léna, H. Didier, A. Hofman, P. Mazieres, J.
Description	Author Affiliation: Guibert N ( Unité d'oncologie cervico-thoracique-clinique des voies respiratoires, service de pneumologie, hôpital Larrey, université Paul-Sabatier, CHU de Toulouse, chemin de Pouvourville, 31059 Toulouse cedex, France. Electronic address: guibert.n@chu-toulouse.fr.); Ilie M ( Laboratoire de pathologie clinique et expérimentale, hôpital Pasteur, 06000 Nice, France.); Léna H ( Service de pneumologie, hôpital Pontchaillou, CHU de Rennes, 35000 Rennes, France.); Didier A ( Unité d'oncologie cervico-thoracique-clinique des voies respiratoires, service de pneumologie, hôpital Larrey, université Paul-Sabatier, CHU de Toulouse, chemin de Pouvourville, 31059 Toulouse cedex, France.); Hofman P ( Laboratoire de pathologie clinique et expérimentale, hôpital Pasteur, 06000 Nice, France.); Mazieres J ( Unité d'oncologie cervico-thoracique-clinique des voies respiratoires, service de pneumologie, hôpital Larrey, université Paul-Sabatier, CHU de Toulouse, chemin de Pouvourville, 31059 Toulouse cedex, France.)
Abstract	A better understanding of oncogenesis and the development of targeted therapies have led to improved outcomes in the treatment of lung cancer. KRAS mutation has the potential to drive the oncogenesis of almost one third of lung adenocarcinomas but it leads to a highly complex proliferation signal involving multiple signaling pathways, explaining the disappointing results of various inhibition strategies of K-ras or its effectors. Nevertheless, recent data suggest different roles of distinct KRAS mutation subtypes and KRAS interactions with new genes in the field of synthetic lethality mechanisms open the way to new therapeutic possibilities. This review aims to provide an overview of: 1) epidemiological data and particularly the prognostic impact of KRAS mutations in non-small cell lung cancer, 2) the results of different drugs either being tested in humans or sources of hope.
File Format	HTM / HTML
ISSN	07618425
Issue Number	2
Journal	Revue des Maladies Respiratoires
Volume Number	33
e-ISSN	17762588
Language	French
Publisher	Elsevier
Publisher Date	2016-02-01
Publisher Place	France
Access Restriction	Subscribed
Subject Keyword	Discipline Pulmonary Medicine
Alternative Title	KRAS and bronchial adenocarcinoma. Between disappointments and hopes
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine

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