NDLI: Glutathione S-transferase enzyme polymorphisms in a Hungarian myelodysplasia study population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Várkonyi, Judit Szakály, Dóra Jánoskúti, Lívia Hosszúfalusi, Nóra Pánczél, Pál Karádi, István Schoket, Bernadette
Spatial Coverage	Hungary
Description	Country affiliation: Hungary Author Affiliation: Várkonyi J ( 3rd Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125, Budapest, Hungary. varkjud@kut.sote.hu)
Abstract	GSTM1, GSTT1 and GSTP1 Ile105Val that are members of the GST gene family encode for Phase II drug/xenobiotic metabolizing enzymes, primarily with detoxifying function, and are polymorphic in humans. GSTM1 and GSTT1 homozygous deletion genotypes do not express the enzymes. It has been hypothesised that individuals with homozygous deletion of the GSTM1 and/or GSTT1 gene may have lower detoxification capacity towards genotoxic agents therefore those individuals may be at increased risk of myelodysplastic syndrome which is a preleukemic condition. Genetic polymorphism of GSTM1, GSTT1 and GSTP1 Ile105Val was investigated in a case-control study in a Hungarian patient population comprising 86 patients with myelodysplastic syndrome and 99 hospital-based controls. There were no statistically significant differences between cases and controls for the GSTM1, GSTT1 and GSTP1 Ile105Val genotype frequencies for any of the three genes separately and in various combinations. This suggests that these genetic polymorphisms may not be strong risk factors, if any, for myelodysplastic syndrome.
File Format	HTM / HTML
ISSN	12194956
Issue Number	4
Volume Number	14
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2008-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Genetic Predisposition To Disease Glutathione Transferase Genetics Myelodysplastic Syndromes Polymorphism, Genetic Adult Aged Aged, 80 And Over Case-control Studies Female Genotype Humans Hungary Male Middle Aged Polymerase Chain Reaction Risk Factors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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