NDLI: Immunohistochemical evaluation of 95 bone marrow reactive plasmacytoses.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ioannou, Maria G. Stathakis, Efstathios Lazaris, Andreas C. Papathomas, Thomas Tsiambas, Evangelos Koukoulis, George K.
Description	Country affiliation: Greece Author Affiliation: Ioannou MG ( Department of Pathology, Medical School, University of Thessaly, Larisa, Greece.)
Abstract	We histologically and immunohistochemically studied 95 bone marrow (BM) reactive plasmacytoses. Ten biopsies from plasma cell myeloma (PCM) patients served as a control group. In addition, we studied 10 monoclonal gammopathy of undetermined significance (MGUS) cases. Histologically, plasmacytosis varied between 5% and 25% with an interstitial pattern of plasma cell (PC) distribution being characteristically displayed. Immunohistochemically, we did not find any CD56/NCAM nor cyclin D1 expression in all biopsies (95 of 95, 100%), not even a weak, doubtful one; PCs were all polyclonal and CD138 positive. On the contrary, myeloma-associated PCs showed monoclonality for kappa- or lambda- light chain and strong CD56/NCAM immunoreactivity (8 of 10, 80%); four of them were cyclin D1 positive. Osteoblasts exhibited similar CD56/NCAM expression in both groups. Our data confirm the diagnostic utility of CD56/NCAM in the phenotypic characterization of polyclonal plasma cells, suggesting an important role of this particular immunomarker in the BM trephine study of polyclonal versus neoplastic plasmacytic infiltrations.
File Format	HTM / HTML
ISSN	12194956
Issue Number	1
Volume Number	15
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2009-03-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Antigens, Cd56 Metabolism Bone Marrow Cyclin D1 Immunoglobulin Lambda-chains Multiple Myeloma Neural Cell Adhesion Molecules Plasma Cells Pathology Humans Immunoenzyme Techniques Retrospective Studies Journal Article
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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