NDLI: Decreased p21 expression in HPV-18 positive cervical carcinomas.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Huang, Lee-Wen Seow, Kok-Min Lee, Chin-Cheng Lin, Yu-Hung Pan, Hun-Shan Chen, Heng-Ju
Description	Country affiliation: Taiwan Author Affiliation: Huang LW ( Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, 95 Wen Chang Road, Shih-Lin District, Taipei, 111, Taiwan. m002057@ms.skh.org.tw)
Abstract	The aim of this study was to investigate the relationship between different human papillomavirus (HPV) genotypes and the expression of p53, p21 and p27 in cervical carcinomas. A total of 103 cases of cervical carcinomas were assayed for expression of p53, p21 and p27 by immunohistochemistry. HPV typing was carried out by two polymerase chain reaction-based methods. Overall, HPV prevalence was 97.1% among the cervical carcinomas in this study. HPV-16 was detected in 66% of the tumors, HPV-18 in 7.8%, HPV-16/18 in 7.8% and other HPV types in 15.5%. The expression of p53 and p27 was not related to HPV genotype. However, in the HPV-18 positive cervical carcinomas, expression of p21 was significantly decreased or completely absent (P = 0.019). Our results indicated that down-regulation of p21 was strongly associated with HPV-18 positive cervical carcinomas. The significantly lower expression of p21 protein in HPV-18 positive samples compared to HPV-18 negative cervical carcinomas supports the hypothesis that inactivation and degradation of p21 proteins by HPV-18 E7 may play an important role in the carcinogenesis of HPV-18 positive cervical neoplasia.
File Format	HTM / HTML
ISSN	12194956
Issue Number	1
Volume Number	16
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2010-03-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Cyclin-dependent Kinase Inhibitor P21 Biosynthesis Papillomavirus Infections Complications Uterine Cervical Neoplasms Metabolism Virology Adult Aged Aged, 80 And Over Genetics Female Human Papillomavirus 16 Human Papillomavirus 18 Humans Immunohistochemistry Middle Aged Epidemiology Prevalence Proliferating Cell Nuclear Antigen Tumor Suppressor Protein P53 Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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