NDLI: Semaphorin 5A, an axon guidance molecule, enhances the invasion and metastasis of human gastric cancer through activation of MMP9.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pan, Guoqing Zhang, Xiangling Ren, Junyu Lu, Jianbo Li, Wenliang Fu, Hongmei Zhang, Shufang Li, Jun
Description	Author Affiliation: Pan G ( Department of Pathology, The First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan, Peoples Republic of China.)
Abstract	Semaphorin 5A, a member of semaphorin family, was originally identified as axonal guidance factor functioning during neuronal development. Previously, we showed that the expression of semaphorin 5A might contribute to the metastasis of gastric cancer. However, its functional roles and mechanism(s) in invasion and metastasis of gastric cancer remain unclear. By using human gastric caner cell lines Parental SGC7901, SGC7901-siScrambled and SGC7901-siSema 5A, we found that semaphorin 5A significantly promoted the invasive and metastatic abilities of gastric cancer cell in vitro. Semaphorin 5A increased the expression of MMP9 by activating phosphorylated ErK1/2 in gastric cancer cell. Furthermore, MEK inhibitor PD98059 and MMP9 antibody (Ab) significantly inhibited in vitro invasive and metastatic abilities induced by semaphorin 5A. Taken together, the present work revealed a novel function of semaphorin 5A that the existence of semaphorin 5A could promote invasion and metastasis of gastric cancer by regulating MMP9 expression, at least partially, via the MEK/ERKs signal transduction pathway. Semaphorin 5A and its regulated molecules could be the potential targets for cancer therapy.
File Format	HTM / HTML
ISSN	12194956
Issue Number	1
Volume Number	19
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2013-01-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Matrix Metalloproteinase 9 Metabolism Membrane Proteins Nerve Tissue Proteins Stomach Neoplasms Pathology Analysis Of Variance Cell Line, Tumor Cell Movement Physiology Flavonoids Pharmacology Humans Integrins Map Kinase Signaling System Biosynthesis Genetics Neoplasm Invasiveness Neoplasm Metastasis Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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