NDLI: Expression of estrogen receptor ß and Ki 67 in benign & malignant human prostate lesions by immunohistochemistry.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Grover, Shrruti K. Agarwal, Sarla Gupta, Sanjay Wadhwa, Neelam Sharma, Nivedita
Description	Author Affiliation: Grover SK ( Department of Pathology, University College of Medical Sciences & GTB Hospital, B-37/7, Double Storey, Ramesh Nagar, New Delhi, 110015, India, shrrutigrover@gmail.com.)
Abstract	Estrogen regulates the growth of prostate through two receptors Estrogen receptor & ß of which ERß is proposed to be antiproliferative. There is a wide variation in the results of various studies regarding the localisation, level of expression of ERß in benign & malignant lesions of prostate and its relation to the grade of tumor emphasizing the need for additional studies to standardize the distribution of this receptor in prostate. This was a prospective study conducted in Department of Pathology, UCMS, Delhi, evaluating ERß & Ki 67 immunoexpression in 60 cases of benign and malignant lesions of prostate (30 each). Tissue for study included prostatic core biopsy and TURP chips. After histomorphological diagnosis, immunohistochemical staining was performed using a monoclonal antibody. Nuclear expression of ERß & Ki67 was evaluated and compared between the two study groups (benign & malignant lesions) using Pearson chi square test. ERß was predominantly localized to nuclei of secretory epithelium of prostatic glands. Expression of ERß was higher in benign glands compared to carcinoma. However, majority of carcinomas retained ERß expression though at much lower levels. Expression of Ki 67 was higher in carcinoma than benign hyperplasia. There was no correlation between the ERß status, Ki 67 expression & grade of tumor. Expression of ERß is downregulated in carcinoma compared to benign hyperplasia and is consistent with its chemopreventive role in prostate. It might have a therapeutic implication as agonists' targeting this receptor could be a part of treatment protocol for those patients of carcinoma who retain this receptor at significant levels.
File Format	HTM / HTML
ISSN	12194956
Issue Number	3
Volume Number	21
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2015-07-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Tumor Markers, Biological Metabolism Estrogen Receptor Beta Ki-67 Antigen Prostatic Hyperplasia Pathology Prostatic Neoplasms Aged Aged, 80 And Over Follow-up Studies Humans Immunoenzyme Techniques Male Middle Aged Neoplasm Grading Neoplasm Staging Prognosis Prospective Studies Comparative Study Journal Article
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in