NDLI: One-Year Neoadjuvant Endocrine Therapy in Breast Cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rusz, Orsolya Vörös, András Varga, Zoltán Kelemen, Gyöngyi Uhercsák, Gabriella Nikolényi, Alíz Ormándi, Katalin Simonka, Zsolt Kahán, Zsuzsanna
Description	Country affiliation: Hungary Author Affiliation: Rusz O ( Department of Oncotherapy, University of Szeged, Korányi fasor 12, 6720, Szeged, Hungary.)
Abstract	The evaluation of the effects of 1-year endocrine therapy (NET) was aimed at. A retrospective analysis of 42 cases with 46 stage II-III invasive, hormone receptor-positive, HER2-negative breast cancers was performed. One-year NET was planned with letrozole (n = 33, postmenopausal group), or with goserelin plus letrozole (n = 7) or with goserelin plus tamoxifen (n = 2) (premenopausal group). Surgery was performed in accordance with the initial stage and the response to therapy. With regard to the tumor remaining in the surgical specimen, risk groups were constructed: Group 1: stage 0, pathological complete regression (pCR); Group 2: stages IA-IIA; Group 3: stages ≥ IIB + cases with clinical progression. Due to local progression, NET was replaced by neoadjuvant chemotherapy in three patients (four tumors). In two postmenopausal patients, letrozole was replaced by tamoxifen because of the insufficient treatment effect. In 19/42 cases, breast-conserving surgery was performed. Within Group 1, there was no cancer in four cases, while only DCIS remained in 2 (pCR: 13 %); Groups 2 and 3 comprised 25 and 15 cases, respectively. The likeliness of a good response (Groups 1 and 2 vs. Group 3) to NET was increased by 7 % for every 1 % increase of the expression of ER (OR = 1.070; 95 % CI: 1.007-1.138, p = 0.029). Progression-free survival differed according to treatment response (p = 0.001). The post-therapy Ki67 value of ≤ 15 % had only a marginal effect on survival. No other associations were detected between the tumor characteristics and the therapeutic response or survival. Long-duration NET is effective and safe in cases of hormone-sensitive breast cancer.
File Format	HTM / HTML
ISSN	12194956
Issue Number	4
Volume Number	21
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2015-09-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Antineoplastic Agents, Hormonal Therapeutic Use Tumor Markers, Biological Metabolism Breast Neoplasms Drug Therapy Carcinoma, Ductal, Breast Carcinoma, Lobular Neoadjuvant Therapy Aged Mortality Pathology Female Follow-up Studies Humans Immunoenzyme Techniques Middle Aged Neoplasm Invasiveness Neoplasm Staging Postmenopause Premenopause Prognosis Receptor, Erbb-2 Receptors, Estrogen Receptors, Progesterone Retrospective Studies Survival Rate Time Factors Journal Article
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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